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Finding Cures. Saving Children.
Carl W. Jackson, PhD
Associate Director of Academic Programs
Departments
Academic Programs in the Biomedical Sciences
Contact Information
Carl W. Jackson, PhD
Academic Programs in the Biomedical Sciences
MS 276, Room DP031F
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-3517
FAX: (901) 595-5376
Email: carl.jackson@stjude.org
Education
PhD - University of Tennessee-Knoxville (1971)
Research Interests
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Megakaryocyte differentiation
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Hemopoiesis
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Hemopoietic regulation
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Platelet function
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Radiation hematology
Selelted Publications
Tiedt R, Coers J, Ziegler S, Wiestner A, Hao-Shen H, Bornmann C, Schenkel J, Karakhanova S, de Sauvage FJ, Jackson CW, Skoda RC. Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood 113:1768-77, 2009.
Prislovsky A, Marathe B, Hosni A, Bolen AL, Nimmerjahn F, Jackson CW, Weiman D, Strom TS. Rapid platelet turnover in WASP(-) mice correlates with increased ex vivo phagocytosis of opsonized WASP(-) platelets. Exp Hematol 36:609-23, 2008.
Liu J, Jackson CW, Gartner TK. The Src requirement for washed platelet aggregation and dense granule secretion in response to stimulation by a low level gamma-thrombin. J Thromb Haemostas 6:1035-37, 2008.
Srivastava DK, Boyett JM, Jackson CW, Tong X, Rai SN. A comparison of permutation Hotelling’s T2 Test and log-ratio test for analyzing compositional data. Communications in Statistics – Theory and Medicine 36:415-431, 2007.
Liu J, Ware J, Jackson CW, Gartner TK. Fcr gamma-chain-dependent alphaIIbbeta3 outside-in signaling. J Thromb Haemost 5:426-428, 2007.
Liu J, Ware J, Jackson CW, Gartner TK. FcR-gamma-chain signals in the absence of glycoprotein VI. Thromb Haemost 5:201-203, 2007.
Sun Y, Boyd K, Xu W, Jackson C, Fu A, Shillingford JM, Robinson GW, Hennighausen L, Hitzler JK, Ma Z, Morris SW. Acute Myeloid Leukemia-Associated Mkl1 (Mrtf-a) is a Key Regulator of Mammary Gland Function. Mol Cell Biol 26:5809-5826, 2006.
Liu J, Fitzgerald MEC, Berndt MC, Jackson CW, Gartner TK. Bruton’s tyrosine kinase is essential for botrocetin/vWf-induced signaling and GPIb-dependent thrombus formation in vivo. Blood 108:2596-2603, 2006.
Liu JL, Pestina TI, Berndt MC, Jackson CW, Gartner TK. Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alpha IIb beta 3- and aggregation-independent manner. Blood 106: 2750-2756, 2005.
Liu JL, Jackson CW, Gruppo RA, Jennings LK, Gartner TK. The beta 3 subunit of the integrin alpha IIb beta 3 regulates alpha IIb-mediated outside-in signaling. Blood 105: 4345-4352, 2005.
Liu J, Jackson CW, Gruppo RA, Jennings LK, Gartner TK. The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb mediated outside-in signaling. Blood 105:4345-52, 2005.
Liu J, Pestina TI, Berndt MC, Steward SA, Jackson CW, Gartner TK. The roles of ADP and TXA in botrocetin/VWF-induced aggregation of washed platelets. J Thromb Haemost 2:2213-22, 2004.
Jackson CW, Tatsuka M, Todokoro K, Ravid K. Aberrant quantity and localization of Aurora-B/AIM-1 and Survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1 deregulated expression. Blood 103:3717-26, 2004.
Pestina TI, Jackson CW. Differential role of stat5 isoforms in effecting hematopoietic recovery induced by Mpl-ligand in lethally myelosuppressed mice. Exp Hematol 31:1198-1205, 2003.
Cho M, Liu J, Pestina TI, Steward SA, Jackson CW, Gartner TK. aIIbb3-mediated outside-in signaling induced by the agonist peptide LSARLAF utilizes ADP and thromboxane A2 receptors to cause a-granule secretion by platelets. J Thromb Haemost 1, 363-373, 2003.
Cho M, Pestina TI, Steward SA, Thomas D, Coffman T, Jackson CW, Gartner TK. The roles of aIIbb3 outside-in mediated signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood 101:2646-2651, 2003.
Inoue A, Seidel MG, Wu W, Kamizono S, Ferrando AA, Bronson RT, Iwasaki H, Akashi K, Morimoto A, Hitzler JK, Pestina TI, Jackson CW, Tanaka R, Chong MJ, McKinnon PJ, Inukai T, Grosveld GC, Look AT. Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell Oct;2(4):279-88, 2002.
Kasper LH, Boussouar F, Ney PA, Jackson CW, Rehg J, van Deursen JM, Brindle PK. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature Oct 17;419(6908):738-43, 2002.
Kaluzhny Y, Yu G, Sun S, Toselli P, Nieswandt B, Jackson CW, Ravid K. BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation. Blood 100:1670-8, 2002.
Cho M, Pestina TI, Steward, SA, Jackson CW, Gartner TK. The roles of LAT in platelet signaling induced by colagen, TxA2 or ADP. Biochem Biophys Res Comm 292:916-921, 2002
Cho MJ, Pestina TI, Steward SA, Lowell CA, Jackson CW, Gartner TK. Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin. Blood 99:2442-2447, 2002.
Kimura Y, Hart A, Hirashima M, Wang C, Holmyard D, Pittman J, Pang X-L, Jackson CW, Bernstein A. Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. J Exp Med 195: 941-952, 2002.
Abushullaih BA, Pestina TI, Srivastava DK, Jackson CW, Daw NC. A schedule of recombinant Mpl ligand highly effective at preventing lethal myelosuppression in mice given carboplatin and radiation. Exp Hematol 29:1425-1431, 2001.
Pestina TI, Cleveland JL, Yang C, Zambetti GP, Jackson CW. Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis. Blood 98: 2084-2090, 2001.
Sun S, Zimmet JM, Toselli P, Thompson A, Jackson CW, Ravid K. Overexpression of cyclin D1 moderately increases ploidy in megakaryocytes. Haematologica Jan;86(1):17-23, 2001.
Jackson CW, Rehg JE, Rock CO, Henning R, Reynolds SD. Computer simulation optimizes airflow design in non-rectangular animal room configurations. Lab Animal Fall pages 50-53, 2001.
Wang D, Feng J, Wen R, Marine J-C, Sangster MY, Parganas E, Jackson CW, Cleveland JL, Murray PJ, Ihle JN. Phospholipase C-g2 is essential in the functions of B cell and Fc receptors. Immunity 13:25-35, 2000.
Sun S, Jackson CW, Ravid K. MAP kinase localizes to the platelet-yielding demarcation membrane system of megakaryocytes. Blood (Letter) 95:1511, 2000.
Luoh S-M, Stefanich E, Solar G, Steinmetz H, Lipari T, Pestina TI, Jackson CW, de Sauvage FJ. Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo. Mol Cell Biol 20:507-515, 2000.
Last update: July 2009
