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Research
| Technology Name (St. Jude Reference #) |
Genetically Engineered Swine Influenza Virus and Uses Thereof (SJ-03-0015) |
| Description | An attenuated swine influenza virus having an impaired ability to antagonize the cellular interferon (IFN) response was developed by modifying the NS1 gene. This attenuated virus is capable of generating an immune response with decreased virulence making it an ideal candidate for live virus vaccine development. |
| Keywords | Swine influenza vaccine, live virus vaccine |
| Granted Patents or Published Applications | Pending U.S. Application published January 8, 2009 as US 2009/0010962, pending applications in Brazil, Canada, China and Europe (Pub. No. 1773384 |
| Related Scientific References | Solorzano A, Webby RJ, Lager KM, Janke BH, Garcia-Sastre A, Richt JA., Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J Virol. 2005 Jun;79(12):7535-43. |
| Licensing Opportunities | This invention is co-owned with Mt. Sinai School of Medicine and the USDA. We are currently looking for licensees in all fields. |
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2010
