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Finding Cures. Saving Children.
Joseph T. Opferman, PhD
Assistant Member, St. Jude Faculty
Departments
Biochemistry
Contact Information
Joseph Opferman, PhD
Biochemistry
MS 340, Room D4063D
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: joseph.opferman@stjude.org
Phone: (901) 595-5524
FAX: (901) 525-8025
Education
BS - Notre Dame University, Notre Dame, Indiana (1995)
PhD - University of Chicago, Chicago, Illinois (2000)
Research Interests
- Apoptosis
- Hematopoiesis
- Development and regulation of the immune system
- Regulation of homeostasis by growth factor signaling
Selected Publications
Steimer DA, Boyd K, Takeuchi O, Fisher JK, Zambetti GP, Opferman JT. Selective Roles for Anti-Apoptotic MCL-1 during granulocyte development and macrophage effector function. Blood 113:2805-15, 2009.
Vick B, Weber A, Urbanik T, Krammer PH, Opferman JT, Schuchmann M, Galle PR, Schulze-Bergkamen H. Knock-out of Myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes. Hepatology 49:627-36, 2009.
Arbour N, Vanderluit JL, Le Grand JN, Jahani-Asl A, Ruzhynsky VA, Cheung ECC, Kelly MA, MacKenzie AE, Park DS, Opferman JT, Slack RS. MCL-1 is a key regulator of apoptosis during CNS development and following DNA damage. J Neuroscience 28:6068-6078, 2008.
Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN. Hax-1 mediated processing of HrtA2/Omi by PARL allows survival of lymphocytes and neurons. Nature 452:98-102, 2008.
Podar K, Gouill SL, Zhang J, Opferman JT, Zorn E, Tai YT, Hideshima T, Amiot M, Chauhan D, Harousseau JL, Anderson KC. A pivotal role for Mcl-1 in Bortezomib-induced apoptosis. Oncogene 27:721-731, 2007.
Woodland RT, Fox CJ, Schmidt MR, Hammerman PS, Opferman JT, Korsmeyer SJ, Hilbert DM, Thompson CB. Multiple signaling pathways promote B lymphocyte stimulator (BLyS)-dependent B cell growth and survival. Blood 111:750-760, 2008.
Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, Kundu M, Opferman JT, Cleveland JL, Miller JL, Ney PA. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci USA 104:19500-19505, 2007.
Opferman JT. Life and death during hematopoietic differentiation. Curr Opin Immunol 19:497-502, 2007.
Opferman JT. Apoptosis in the development of the immune system. Cell Death Differ 15:234-242, 2007.
Wei G, Twomey D, Lamb J, Schlis K, Agarwal J, Stam RW, Opferman JT, Sallan SE, den Boer ML, Pieters R, Golub TR, Armstrong SA. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL-1 and glucocorticoid resistance. Cancer Cell 10:331-342, 2006.
Opferman JT. Unraveling MCL-1 degradation. Cell Death Differ 13:1260-1262, 2006.
Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ. Proapoptotic BAX and BAK control multiple initiator caspases. EMBO J 6:379-385, 2005.
Opferman JT, Iwasaki H, Ong CC, Suh H, Mizuno S-I, Akashi K, Korsmeyer SJ. Obligate Role of Anti-apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells. Science Science 307:1101-1104, 2005.
Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ. Proapoptotic BAX and BAK regulate the type I inositol triphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci USA 102:105-110, 2005.
Phillips T, Opferman JT, Shah R, Liu N, Froelich CJ, Ashton-Rickardt PG. A Role for the Granzyme B Inhibitor Serine Protease Inhibitor 6 in CD8+ Memory Cell Homeostasis. J Immunol 173:3801-3809, 2004.
Liu N, Phillips T, Zhang M, Wang Y, Opferman JT, Shah R, Ashton-Rickardt PG. Serine protease inhibitor 2A is a protective factor for memory T cell development. Nature Immunology 5:919-926, 2004.
Mori M, Burgess DL, Gefrides LA, Foreman PJ, Opferman JT, Korsmeyer SJ, Cavalheiro EA, Naffah-Mazzacoratti MdG, Noebels JL. Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons. Cell Death and Differentiation 11:1223-1233, 2004.
Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ. Development and Maintenance of B and T Lymphocytes Requires Anti-Apoptotic MCL-1. Nature 426:671-676, 2003.
Oakes SA, Opferman JT, Pozzan T, Korsmeyer SJ, Scorrano L. Regulation of endoplasmic reticulum Ca(2+) dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol 66:1335-40, 2003.
Opferman JT, Korsmeyer SJ. Apoptosis in the Development and Maintenance of the Immune System. Nature Immunology 4:410-415, 2003.
Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T, Korsmeyer SJ. Regulation of endoplasmic reticulum Ca2+ dynamics by BAX, BAK is a control point for apoptosis. Science 300:135-139, 2003.
Hettmann T, Opferman JT, Leiden JM, Ashton-Rickardt PG. A critical role for NF-[kappa]B transcription factors in the development of CD8+ memory-phenotype T cells. Immunology Letters 85:297-300 2003.
Opferman JT, Ober BT, Narayanna R, Ashton-Rickardt PG. Suicide induced by cytolytic activity controls the differentiation of memory CD8+ T lymphocytes. Int Immunol 13:411-419, 2001.
Ober BT, Hu Q, Opferman JT, Hagevich S, Chiu N, Wang CR, Ashton-Rickardt PG. Affinity of thymic self-peptides for the TCR determines the selection of CD8+ T lymphocytes in the thymus. Int Immunol 12:1353-1363, 2000.
Ashton-Rickardt PG, Opferman JT. Memory T lymphocytes. CMLS: Cellular and Molecular Life Sciences 56:69-77, 2000.
Thompson CB, Rathmell JC, Frauwirth KA, Lindsten T, Rudin CM, Opferman JT, Ashton-Rickardt PG, Harris MH, Chandel NS, Schumacker PT, Vander Heiden MG. What keeps a resting T cell alive? Cold Spring Harb Symp Quant Biol 64:383-387, 1999.
Opferman JT, Ober BT, Ashton-Rickardt PG. Linear differentiation of cytotoxic effectors into memory T lymphocytes. Science 283:1745-1748, 1999.
Markiewicz M, Girao C, Opferman JT, Sun J, Hu Q, Agulnik A, Bishop C, Thompson CB, Ashton-Rickardt PG. Long-term T cell memory requires the surface expression of self-peptide/major histocompability complex molecules. Proc Natl Acad Sci USA 95:3065-3070, 1998.
Hu Q, Walker CRB, Girao C, Opferman JT, Sun J, Shabanowitz J, Hunt DF, Ashton-Rickardt PG. Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes. Immunity 7:221-231, 1997.
McAbee DD, Nowatzke W, Oehler C, Sitaram M, Sbaschnig E, Opferman JT, Carr J, Ebensen K. Endocytosis and degradation of bovine apo- and holo-lactoferrin by isolated rat hepatocytes are mediated by recycling calcium-dependent binding sites. Biochemistry 32:13749-13760, 1993.
Last update: June 2009
