Related Topics

Non-Therapeutic Protocol

GENIOS: Genes Influencing Iron Overload State

Type of Protocol/Clinical Study

Associated Hematology Studies, Supportive Studies: Genetics


Iron overload, defined as too much iron in the body, may develop when someone has many blood transfusions, or because of inherited defects . Iron can build up in several organs in the body, such as the heart, liver, endocrine glands (pancreas, thyroid, etc.), and spleen. Too much iron can damage organs and may even cause death. Therefore, iron overload needs to be appropriately watched and treated to avoid unnecessary disease or death. Iron builds up differently in different people, and in different organs of the body. Some people build up iron faster than others, even when receiving the same number of blood transfusions.

This study will investigate whether genes have any influence on how much iron accumulates in the body, especially in the liver, heart, and other abdominal organs. We will also investigate if certain genes influence how iron exits the body.The duration of the study will be for six years.



Principal Investigator

Jane Hankins, MD, MS

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