Shannon McKinney-Freeman, PhD

Shannon McKinney-Freeman

Assistant Member, St. Jude Faculty




Experimental Hematology

Contact Information

Shannon McKinney-Freeman
MS 341, Room D3007E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-2733
FAX: (901) 595-4723


PhD – Baylor College of Medicine, Houston, Texas

Research Interests

Research lab

Selected Publications

Arora N, Wenzel PL, McKinney-Freeman SL, Ross SJ, Kim PG, Chou SS, Yoshimoto M, Yoder MC, Daley GQ. Effect of Developmental Stage of HSC and Recipient on Transplant Outcomes. Dev Cell Jun 9;29(5):621-8. PMID: 24914562

Holmfeldt P, Pardieck J, Saulsberry A, Kumar-Nandakumar S, Finkelstein D, Gray JT, Persons DA, McKinney-Freeman SL. Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival. Blood 2013 (in press).

Gustafsson K, Heffner G, Wenzel PL, Curran M, Grawé J, McKinney-Freeman SL, Daley GQ, Welsh M. The Src Homology 2 Protein Shb Promotes Cell Cycle Progression In Murine Hematopoietic Stem Cells By Regulation Of Focal Adhesion Kinase Activity. Exp Cell Res Mar 22, 2013. [Epub ahead of print] PMID:23528453

McKinney-Freeman S, Cahan P, Li H, Lacadie SA, Huang HT, Curran M, Loewer S, Naveiras O, Kathrein KL, Konantz M, Lengerke C, Zon LI, Collins JJ, Daley GQ. The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell Nov 2;11(5):701-14, 2012. * Cover Article

Kim K, Doi A, Wen B, Ng K, Zhao R1, Cahan P, Kim J, Ji H, Ehrlich L, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, Mckinney-Freeman S, Naveiras O, Yoon T, Hanna J, Jaenisch R, Weissleder R, Orkin S, Weissman IL, Feinberg A, Daley GQ. Epigenetic memory in induced pluripotent stem cells. Nature Sept 16;467: 285-90, 2010.

Koo S, Huntly BJ , Wang Y, Chen J, Brumme K, Ball B, McKinney-Freeman SL, Yabuuchi A, Scholl C, Bansal D, Zon LI, Fröhling S, Daley GQ, Gilliland DG, Mercher T. Cdx4 is dispensable for murine adult hematopoiesis but promotes MLL-AF9-mediated leukemogenesis. Haematologica Oct; 95: 1642-50, 2010.

Adamo L, Naveiras O, Wenzel PL, McKinney-Freeman S, Mack PJ, Gracia-Sancho J, Suchy-Dicey A, Yoshimoto M, Lensch MW, Yoder MC, García-Cardeña G, Daley GQ. Biomechanical forces promote embryonic haematopoiesis. Nature June 25; 459: 1131-5, 2009.

McKinney-Freeman SL, Naveiras O, Yates F, Loewer S, Philitas M, Curran M, Park PJ, Daley GQ. Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells. Blood July 9;114: 268-78, 2009.

McKinney-Freeman S, Naveiras O, Daley GQ. Isolation of Hematopoietic Stem Cells from Mouse Embryonic Stem Cells. Current Protocols in Stem Cell Biology Feb;Chapter 1:Unit 1F.3, 2008.

McKinney-Freeman S, Lengerke C, Jang I-H, Shea J, Schmitt S, Philitas M, Wang Y, Daley GQ. Modulation of embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes. Blood May 15; 111: 4944-53, 2008. * Cover article

Wang Y, Yabuuchi A, McKinney-Freeman S, Scott G, Ward T, Ray M, Ducharme DMK, Chawengsaksophak K, Archer TK, Daley GQ. Cdx gene deficiency compromises embryonic hematopoiesis in the mouse. PNAS June; 105: 7756-61, 2008.

Lengerke C, Schmitt S, Bowman T, Maouche-Chretien L, McKinney-Freeman S, Jang I-L, Hammerschmidt M, Davidson AL, Green J, Zon LI and Daley GQ. BMP and Wnt Specify Hemogenic Mesoderm by Activation of the Cdx-Hox Pathway From Murine Embryonic Stem Cells. Cell Stem Cells 2: 72-82, 2008.

McKinney-Freeman SL, Daley GQ. Towards hematopoietic reconstitution from embryonic stem cells: a sanguine future. Current Opinion in Hematology 14(4):343-347, 2007.

McKinney-Freeman S, Naveiras O, Daley GQ. Derivation of hematopoietic stem cells from murine embryonic stem cells. Journal of Visualized Science Feb 25;(2):162, 2007.

Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA. Differential mRNA Processing in Hematopoietic Stem Cells. Stem Cells Mar, 24(9): 662-70, 2006.

McKinney-Freeman SL. Phenotype and origin of human skeletal muscle-derived hematopoietic progenitors. Leukemia Research 29(4):363-4, 2005.

McKinney-Freeman SL, Goodell MA. Muscle-Derived Hematopoietic Stem Cells. Book Chapter: The Handbook of Stem Cells. Handbook of Stem Cells, Volume 2: Adult and Fetal Stem Cells Book Chapter: Muscle-derived Hematopoietic Stem Cells, Robert Lanza, (ed.), Elsevier Academic Press, pp. 405, 2004.

McKinney-Freeman SL, Goodell MA. Circulating Hematopoietic Stem Cells Do Not Efficiently Home to Bone Marrow During Homeostasis. Experimental Hematology Sep;32(9):868-76, 2004.

McKinney-Freeman SL, Majka S, Jackson KA, Norwood K, Hirschi K, Goodell MA. Altered Phenotype and Reduced Function of Muscle-Derived Hematopoietic Stem Cells. Experimental Hematology Sep, 31(9):806-14, 2003.

McKinney-Freeman SL, Jackson KA, Camargo FD, Ferrari G, Mavilio F, Goodell MA. Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proceedings of the National Academy of Sciences Feb 5;99(3):1341-6, 2002.

Bartemes KR, McKinney S, Gleich GJ, Kita H. Endogenous platelet-activating factor is critically involved in effector functions of eosinophils stimulated with IL-5 or IgG. Journal of Immunology March 1; 162(5): 2982-9, 1999.

Last update: June 2014