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Associate Member, St. Jude Faculty
Maureen McGargill, PhD
MS 351, Room E7055
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-6307
FAX: (901) 595-5766
PhD - University of Minnesota, Minneapolis (2000)
The goal of our research is to understand how self-reactive T cells develop and induce autoimmune diseases such as type 1 diabetes, multiple sclerosis, and inflammatory bowel disease. We wish to identify a means to specifically target the harmful T cells, while sparing the useful T cells that are important for eliminating infectious pathogens.
Keating R, Hertz T, Wehenkel M, Harris TL, Edwards BA, McClaren JL, Brown SA, Surman S, Wilson ZS, Bradley P, Hurwitz J, Chi H, Doherty PC, Thomas PG, McGargill MA. The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol 14(12):1266-1276, 2013.
Shaw PJ, Barr MJ, Lukens JR, McGargill MA, Chi H, Mak TW, Kanneganti TD. Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity. Immunity 34:75-84, 2011.
Kerdiles YM, Stone EL, Beisner DL, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick SM. Foxo transcription factors control regulatory T cell development and function. Immunity 33:890-904, 2010.
Shaw PJ, Lukens JR, Burns S, Chi H, McGargill MA, Kanneganti TD. Cutting Edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. Journal of Immunology 184:4610-4, 2010.
McGargill MA, Ch’en IL, Katayama CD, Pages G, Pouyssegur, J, Hedrick SM. Cutting Edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. Journal of Immunology 183:4838-42, 2009.
Hayashi T, Gray C, Chan M, Tawatao R, Lisa Ronacher L, McGargill MA, Datta S, Carson D, Corr M. Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. Proceedings of the National Academy of Sciences 106:2764-9, 2009.
McGargill MA, Choy C, Wen BG, Hedrick SM. Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. Journal of Immunology 20181:7593-7605, 2008.
Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. Journal of Immunology 181:2084-91, 2008.
McGargill MA, Sharp LL, Bui JD, Hedrick SM, Calbo S. Active Ca2 /calmodulin-dependent protein kinase IIgammaB impairs positive selection of T cells by modulating TCR signaling. Journal of Immunology 175:656-64, 2005.
McGargill MA, Wen BG, Walsh CM, Hedrick SM. A deficiency in Drak2 results in a T cell hypersensitivity, and an unexpected resistance to autoimmunity. Immunity 6:781-91, 2004.
McGargill MA, Mayerova D, Stefanski HE, Koehn B, Parke EA, Jameson SJ, Panoskaltsis-Mortari A, Hogquist KA. A spontaneous CD8 T cell dependent autoimmune disease to an antigen expressed under the Human Keratin 14 Promoter. Journal of Immunology 169:2141-2147, 2002.
McGargill MA, Derbinski J, Hogquist KA. Receptor editing in developing T cells. Nature Immunology 1:336-341, 2000.
McGargill MA, Hogquist KA. Antigen-induced co-receptor downregulation on thymocytes is not a result of apoptosis. Journal of Immunology 162:1237-1245, 1999.
Hogquist KA, Tomlinson AJ, Kieper WC, McGargill MA, Naylor S, Jameson SC. Identification of a naturally occurring ligand for thymic positive selection. Immunity 6(4):389-399, 1997.
Last updated: January 2014