Patricia M. Flynn, MD

Patricia M. Flynn, MD

Member, St. Jude Faculty
Arthur Ashe Chair in Pediatric AIDS Research
Director, Clinical Research, Infectious Diseases
Director, Translational Trials Unit
Co-Leader, HIV Therapeutics & Vaccine Development, CIDC

Departments

Infectious Diseases

Contact Information

Patricia Flynn, MD
Infectious Diseases
MS 600, Room Q1114
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: pat.flynn@stjude.org
Phone: (901) 595-2338
FAX: (901) 595-5068

Education

BS - Rhodes College (formerly Southwestern at Memphis), Memphis, Tennessee (1977)
MS - Epidemiology, University of Tennessee, Memphis, College of Graduate Health (2002)
MD - Louisiana State University Medical Center, New Orleans, Louisiana (1981)


Research Interests

  • Infections in immunocompromised hosts (mycotic infections and intravascular catheter infections)
  • AIDS
  • Epidemiology

AIDS Clinical Trials


Selected Publications

Garvie PA, Lawford J, Gaur AH, Belzer M, McSherry GD, Hu C, Flynn PM, for the Pediatric AIDS Clinical Trials Group 1036A Study Team. Development of a Modified Directly Observed Therapy (MDOT) Adherence Intervention for Adolescents with HIV-1: Application of Focus Group Methodology to Inform Design, Feasibility and Acceptability. J Adolesc Health 44:124-132, 2009.  (NIHMS92198).

Kiser JJ, Fletcher CV, Flynn PM, Cunningham CK, Wilson CM, Kapogiannis BG, Major-Wilson H, Viani RM, Liu NX, Muenz LR, Harris DR, Havens PL. Adolescent Trials Network for HIV/AIDS Interventions. Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection. Antimicrob Agents Chemother Feb;52(2):631-7, 2008. Epub 2007 Nov 19.

Kurt B, Flynn P, Shenep JL, Pounds S, Lensing S, Ribeiro RC, Pui CH, Razzouk BI, Rubnitz JE. Prophylactic antibiotics reduce morbidity due to septicemia during intensive treatment for pediatric acute myeloid leukemia. Cancer May 5, 2008. [Epub ahead of print]

Agwu A, Lindsey JC, Ferguson K, Zhang H, Spector S, Rudy BJ, Ray SC, Douglas SD, Flynn PM, Persaud D; and the Pediatric AIDS Clinical Trials Group 381 Study Team. Analyses of HIV-1 Drug-Resistance Profiles Among Infected Adolescents Experiencing Delayed Antiretroviral Treatment Switch After Initial Nonsuppressive Highly Active Antiretroviral Therapy. AIDS Patient Care STDS May 15, 2008. [Epub ahead of print].

McKinney RE Jr, Rodman J, Hu C, Britto P, Hughes M, Smith ME, Serchuck LK, Kraimer J, Ortiz AA, Flynn P, Yogev R, Spector S, Draper L, Tran P, Scites M, Dickover R, Weinberg A, Cunningham C, Abrams E, Blum MR, Chittick GE, Reynolds L, Rathore M. Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021. Pediatrics 120:e416–23, 2007.

Hope WW Seibel NL, Schwartz CL, Arrieta A, Flynn P, Shad A, Albano E, Keirns JJ, Buell DN, Gumbo T, Drusano GL, Walsh TJ. Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing. Antimicrob Agents Chemother 51:3714-3719, 2007.

Flynn PM, Rodman J, Lindsey JC, Robbins B, Capparelli E, Knapp KM, Rodriguez JF, McNamara J, Serchuck L, Heckman B, Martinez J, and the PACTG P1012 Team. Intracellular Pharmacokinetics of Once vs. Twice Daily Zidovudine and Lamivudine in Adolescents. Antimicrob Agents Chemother 51:3516-3522, 2007.

Flynn P, Havens P, Brady M. Emmanuel P, Read J, Hoyt L, Henry-Reid L, VanDyke R, Mofenson L. Male circumcision for prevention of HIV and other sexually transmitted diseases. Pediatr 119:821-22, 2007.

Flynn PM, Rudy BJ, Lindsey JC, Douglas SD, Lathey J, Spector SA, Martinez J, Silio M, Belzer M, Smith E, Hodge J, Hughes MD. Long-term observation of adolescents initiating HAART therapy: three year follow up. AIDS Res Hum Retroviruses Oct;23(10):1208-14, 2007.

Madden RM, Pui C-H, Flynn PM, Leung W. Prophylaxis of Pneumocystis carinii pneumonia with atovaquone in children with leukemia. Cancer 109:1654-8, 2007.

Zhou Z, Rodman JH, Flynn PM, et al. Model for intracellular lamivudine metabolism in peripheral blood mononuclear cellls ex vivo and in human immunodeficiency virus type-1 infected adolescents. Antimicrob Agents Chemother 50:2686-2694, 2006.

Rudy BJ, Lindsey JC, Flynn PM, Bosch RJ, Wilson CM, Hughes ME, Douglas SD and the PACTG Protocol 381 Study Team. Immune reconstitution and predictors of virologic failure in adolescnets infected through high risk behaviors and initiating HAART: week 60 results from the PACTG 381 cohort. AIDS Res Hum Retroviruses 22:213-21, 2006.

Denning DW, Marr KA, Lau WM, Facklam D, Ratanatharathorn V, Niederwieser D, Ullmann AJ, Seibel N, Flynn P, van Burik J, Buell DN, Patterson TF. Micafungin (FK463), Alone or in Combination With Other Systemic Antifungal Agents, for the Treatment of Acute Invasive Aspergillosis. J Infect 53:337-349, 2006.

Seibel NL, Schwartz C, Arrieta A, Flynn P, Shad A, Albano E, Keirns J, Lau WM, Facklam DP, Buell DN, Walsh TJ. Safety, tolerability, and pharmacokinetics of Micagunfin (FK463) in febrile, neutropenic pediatric patients. Antimicrob Agents Chemother 49:3317-24, 2005.

Miller, M, Obert, CA, Gao G, Daw, NC, Flynn P, Tuomanen E. High level cephalosporin-resistant pneumococci in patients with sickle cell disease. Emerg Infect Dis 11:1192-6, 2005.

Rutstein R, Gebo KA, Siberry GK, Flynn PM, Spector SA, Sharp VL, Fleishman JA. Hospital and outpatient health services utilization among HIV-infected children in care 2000-2001. Medical Care 43:III3-9, 2005.

Kadivar H, Garvie PA, Sinnock C, Heston JD, Flynn PM. Psychosocial profile of HIV-infected adolescents in a Southern US urban cohort. AIDS Care 18:544-9, 2006.

Chadwick EG, Rodman J, Britto P, Powell C, Palumbo P, Luzuriaga K, Hughes M, Abrams E, Flynn PM, Borkowsky W, Yogev R, and the PACTG Protocol 345 Team. Ritonavir-based highly active antiretroviral therapy in HIV-1 infected infants <24 months of age. Pediatr Infect Dis J 24:793-800, 2005.

Walsh TJ, Adamson PC, Seibel NL, Flynn PM, Neely MN, Schwartz C, Shad A, Kaplan S, Roden MM, Stone JA, Miller A, Bradshaw SK, Li SX, Sable CA, Kartonis NA. Pharmacokinetics, safety, and tolerability of caspofungin in children and adolescents. Antimicrob Agents Chemother 49:4536-45, 2005.

Rutstein RM, Gebo KA, Flynn PM, Fleishman JA, Sharp VL, Siberry GK, Spector SA. Immunologic function and virologic suppression among children with perinatally-acquired HIV-infected on HAART. Medical Care 43:III15-2, 2005.

Knapp KM, Flynn PM. Newer treatments for fungal infection. J Support Oncol 3:290-8, 2005.

Gaur AH, Flynn PM, Heine DJ, Giannini MA, Shenep JL, Hayden RT. Diagnosis of catheter-related bloodstream infection among pediatric oncology patients lacking a peripheral culture, using differential time to detection. Pediatr Infect Dis J 24:445-9, 2005.

McCarthy ML, Wilson MW, Fleming JC, Thompson JW, Sandlund JT, Flynn PM, Knapp KM, Haik BG, Ribiero RC. Manifestations of fungal cellulitis of the orbit in children with neutropenia and fever. Ophthal Plast Reconstr Surg 20:217-23, 2004.

Wu H, Lathey J, Ruan P, Douglas SD, Spector SA, Lindsey J, Hughes MD, Rudy BJ and Flynn PM for the PACTG 381 team. Relationship of plasma HIV-! RNA dynamics to baseline factors and virologic responses to hightly active antiretroviral therapy in adolescents (aged 12-22 years) infected through high-risk behavior. J Infect Dis 189:593-601, 2004.

Flynn PM, Rudy BJ, Douglas SD, Lathey J, Spector SA, Martinez J, Silio M, Belzer M, McNamara J, Hodge J, Hughes MD, Lindsey JC. Virologic and immunologic outcome after 24 weeks in HIV-1 infected adolescents in highly active antiretroviral therapy. J Infect Dis 190:271-9, 2004.

Gaur AH, Flynn PM, Shenep JL. Optimum management of pediatric patients with fever and neutropenia. Indian J Pediatr 71:825-35, 2004.

Flynn PM, Willis B, Gaur AH, Shenep JL. Catheter Design Influences Recurrence of Catheter-Related Bloodstream Infection in Children with Cancer. J Clin Oncol 21:3520-5, 2003.

Franklin JA, Gaur AH, Shenep JL, Hu XJ, Flynn PM. In-Situ Diagnosis of Central Venous Catheter-Related Bloodstream Infection without Peripheral Blood Culture. Pediatr Infect Dis J 23:614-8, 2004.

Wang LH, Wiznia AA, Rathore MH, Chittick GE, Bakshi SS, Emmanuel PJ, Flynn PM. Pharmacokinetics and safety of single doses of emtricitabine (Coviracil®) in HIV-infected children. Antimicrob Agents Chemother 48:217-23, 2004.

Last update: May 2009

Email This Article Email This Article   |   Print Print