Charles Russell

    Charles J. Russell, PhD

    Associate Member, St. Jude Faculty

    Departments

    Infectious Diseases

    Divisions

    Virology

    Contact Information

    Charles Russell, PhD
    Infectious Diseases
    MS 330, Room I-6309
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: charles.russell@stjude.org
    Phone: (901) 595-5648
    FAX: (901) 595-8559

    Education

    PhD - University of California at Berkeley
    BS - Chemistry, Millikin University


    Research Interests


    Selected Publications

    Burke CW, Bridges O, Brown S, Rahija R, Russell CJ. Mode of parainfluenza virus transmission determines the dynamics of primary infection and protection from reinfection. PLoS Pathogens 2013 (in press).

    Zaraket H, Bridges OA, Duan S, Baranovich T, Yoon S-W, Reed ML, Salomon R, Webby RJ, Webster RG, Russell CJ. Increased hemagglutinin protein stability enhances H5N1 influenza virus growth in the nasopharynx but is insufficient for transmission in ferrets. J Virol 87:9911-9922, 2013.

    Fouchier RAM, Kawaoka Y, Carona C, Compans RW, Garcia-Sastre A, Govorkova EA, Guan Y, Herfst S, Orenstein WA, Peiris JSM, Perez DR, Richt J, Russell C, Schultz-Cherry SL, Smith DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG. Gain-of-Function experiments on H7N9. Science 341:612-613, 2013.

    Mason JN, Elbahesh H, Russell CJ. Influence of antigen insertion site and vector dose on immunogenicity and protective capacity in Sendai virus-based human parainfluenza virus type 3 vaccines. J Virol 87:5959-5969, 2013.

    Galloway SE, Reed ML, Russell CJ, Steinhauer DA. Influenza HA subtypes demonstrate divergent phenotypes for cleavage activation and pH of fusion: implications for host range and adaptation. PLoS Pathogens 9:e1003151, 2013.

    Zaraket H, Bridges OA, Russell CJ. The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in mice. J Virol 87:4826-4834, 2013. Spotlight article of significant interest selected by the Editors.

    Russell CJ. Stalking Influenza Diversity with a Universal Antibody. The New England Journal of Medicine 365:1541-2, 2011.

    DuBois RM*, Zaraket H*, Reddivari M, Heath RJ, White SW, Russell CJ. Acid stability of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity. PLoS Pathogens 7:e1002398, 2011. *joint 1st author

    Burke CW*, Mason JN*, Surman SL, Jones BG, Dalloneau E, Hurwitz JL, Russell CJ. Illumination of parainfluenza virus infection and transmission in living animals reveals a tissue-specific dichotomy. PLoS Pathogens 7:e1002134, 2011. *joint 1st author

    DuBois RM, Aguilar‐Yañez JM, Mendoza‐Ochoa GI, Oropeza-Almazán Y, Schultz-Cherry S, Alvarez MM, White SW, Russell CJ. The receptor-binding domain of influenza virus hemagglutinin protein produced in Escherichia coli folds into its native, immunogenic structure. J Virol 85:865-872, 2011.

    Vanderlinden E, Göktaş F, Cesur Z, Froeyen M, Reed ML, Russell CJ, Cesur N, Naesens L. Novel inhibitors of influenza virus fusion: structure activity relationship and interaction with the viral hemagglutinin. J Virol 84:4277-4288, 2010.

    Reed ML, Bridges OA, Seiler P, Kim J-K, Yen H-L, Salomon R, Govorkova EA, Webster RG, Russell CJ. The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks. J Virol 84:1527-1535, 2010.

    Luque LE, Bridges OA, Mason JN, Boyd KL, Portner A, Russell CJ. Residues in the heptad repeat A region of the fusion (F) protein modulate the virulence of Sendai virus in mice. J Virol 84:810-821, 2010. Spotlight article of significant interest selected by authors.

    Boyd V, Mason J, Hanumesh P, Price J, Russell CJ, Webb TR. 2-Substituted-4,5-Dihydroxypyrimidine-6-Carboxamide RNA-Dependent RNA Polymerase Targeted Libraries. J Combinatorial Chem 11:1100-1104, 2009.

    Watanabe M, Mishin VP, Brown SA, Russell CJ, Boyd K, Babu YS, Taylor G, Xiong X, Yan X, Portner A, Alymova IV. Effect of hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 on growth and pathogenicity of Sendai/human parainfluenza type 3 chimera virus in mice. Antimicrob Agents Chemother 53:3942-3951, 2009.

    Reed ML, Yen H-L, DuBois RM, Bridges OA, Salomon R, Webster RG, Russell CJ. Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin (HA) protein. J Virol 83:3568-3580, 2009.

    Jones B, Zhan X, Mishin V, Slobod KS, Surman S, Russell CJ, Portner A, Hurwitz JL. Human PIV-2 recombinant Sendai virus (rSeV) elicits durable immunity and combines with two additional rSeVs to protect against hPIV-1, hPIV-2, hPIV-3, and RSV. Vaccine 27:1848-1857, 2009.

    Zhan X, Slobod KS, Krishnamurthy S, Luque LE, Takimoto T, Jones B, Surman S, Russell CJ, Portner A, Hurwitz JL. Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections. Vaccine 26:3480-3488, 2008.

    Luque LE, Russell CJ. Spring-loaded heptad repeat residues regulate the expression and activation of the paramyxovirus fusion (F) protein. J Virol 81:3130-3141, 2007.

    Russell CJ, Luque LE. The structural basis of paramyxovirus invasion. Trends Microbiol 14:243-246, 2006.

    Russell CJ, Webster RG. The genesis of a pandemic influenza virus. Cell 123:368-371, 2005.

    Russell CJ, Jardetzky TS, Lamb RA. Conserved glycine residues in the fusion peptide of the paramyxovirus fusion protein regulate activation of the native state. J Virol 78:13727-13742, 2004.

    Waning DL, Russell CJ, Jardetzky TS, Lamb RA. Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail. Proc Natl Acad Sci USA 101:9217-9222, 2004.

    Russell CJ, Kantor KL, Jardetzky TS, Lamb RA. A dual-functional paramyxovirus F protein regulatory switch segment: activation and membrane fusion. J Cell Biol 163:363-374, 2003.

    Takeda M, Leser GP, Russell CJ, Lamb RA. Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion. Proc Natl Acad Sci USA 100:14610-14617, 2003.

    Russell CJ, Jardetzky TS, Lamb RA. Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion. EMBO Journal 20:4024-4034, 2001.

    Last update: October 2013