Suzanne Jackowski, PhD

Suzanne Jackowski, PhD

Member, St. Jude Faculty

Departments

Infectious Diseases

Contact Information

Suzanne Jackowski, PhD
Infectious Diseases
MS 320, Room E-8051
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: suzanne.jackowski@stjude.org
Phone: (901) 595-3494
FAX: (901) 595-3099

Education

BA - Canisius College, Buffalo, New York
PhD - University of Tennessee, Graduate School of Biomedical Science, Oak Ridge National Laboratory


Research Interests

  • Regulation of phospholipid homeostasis
  • Control of intracellular coenzyme A content
  • Phospholipid metabolism and membrane stress responses
  • Pantothenate kinase as a target for small molecule therapeutics

Jackowski Research


Selected Publications

Bommiasamy H, Back SH, Fagone P, Lee K, Meshinchi S, Vink E, Sriburi R, Frank M, Jackowski S, Kaufman RJ, Brewer JW. ATF6 and Induction of XBP-1-independent expansion of the endoplasmic reticulum. J Cell Science 122: 1626-1636, 2009.

Fagone P, Gunter C, Sage CR, Gunn KE, Brewer JW, Jackowski S. CTP:phosphocholine cytidylyltransferase α is required for B-cell proliferation and class switch recombination. J Biol Chem 284: 6847-6854, 2009.

Tian Y, Pate C, Andreolotti A, Wang L, Tuomanen E, Boyd K, Claro E, Jackowski S. Cytokine secretion requires phosphatidylcholine synthesis. J Cell Biol 181:945-957, 2008.

Hong B-S, Senisterra G. Rabeh W, Vedadi M, Leonardi R, Zhang Y-M, Rock CO, Jackowski S, Park H-W. Crystal structures of human pantothenate kinases: Insight into allosteric regulation and neurodegeneration disorder. J Biol Chem 282:27984-27993, 2007.

Leonardi R, Zhang Y-M, Lykidis A, Rock CO, Jackowski S. Localization and regulation of mouse pantothenate kinase 2. FEBS Lett 581:4639-4644, 2007.

Gunter C, Frank M, Tian Y, Murti KG, Rehg JE, Jackowski S. Probucol therapy overcomes the reproductive defect in CTP:phosphocholine cytidylyltransferase ß2 Knockout Mice. Biochim Biophys Acta 1771: 845-852, 2007.

Zhang Y-M, Chohnan S, Virga KG, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Newgard CB, Lee RE, Rock CO, Jackowski S. Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. Chem & Biol 14:291-302, 2007.

Fagone P, Sriburi R, Frank M, Wang J, Gunter C, Brewer JW, Jackowski S. Phospholipid biosynthesis program underlying membrane expansion during B-lymphocyte differentiation. J Biol Chem 282:7591-7605, 2007.

Sriburi R, Buldak GL, Robbins GR, Frank M, Jackowski S, Brewer JW. Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. J Biol Chem 282:7024-7034, 2007.

Leonardi R, Rock CO, Jackowski S, Zhang Y-M. Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine. Proc Nat Acad Sci USA 104:1494-1499, 2007.

Nicely NI, Parsonage D, Paige C, Newton GL, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A. Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: Implications for coenzyme A-dependent redox biology. Biochem 46:3234-3245, 2007.

Tian Y, Zhou R, Rehg JE, Jackowski S. Role of phosphocholine cytidylyltransferase a in lung development. Mol Cell Biol 27:975-982, 2007.

Tian Y, Jackson P, Gunter C, Wang J, Rock CO, Jackowski S. Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2. J Biol Chem 281:28438-28449, 2006.

Hong B-S, Yun M-K, Zhang Y-M, Chohnan S, Rock CO, White SW, Jackowski S, Park H-W, Leonardi R. Type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties. Structure 14:1251-1261, 2006.

Zhang Y-M, Rock CO, Jackowski S. Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration. J Biol Chem 281:107-114, 2006.

Virga KG, Zhang Y-M, Leonardi R, Ivey RA, Hevener K, Park H-W, Jackowski S, Rock CO, Lee RE. Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors. Bioorg Med Chem 14:1007-1020, 2006.

Zhang Y-M, Rock CO, Jackowski S. Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters. J Biol Chem 280:32594-32601, 2005.

Wang L, Magdaleno S, Tabas I, Jackowski S. Early embryonic lethality in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferase α (Pcyt1a) Gene. Mol Cell Biol 25:3357-3363, 2005.

Leonardi R, Chonan S, Zhang Y-M, Virga KG, Lee RE, Rock CO, Jackowski S. A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation of coenzyme A. J Biol Chem 280:3314-3322, 2005.

Zhang Y-M, Frank MW, Virga KG, Lee RE, Rock CO, Jackowski S. Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites. J Biol Chem 279:50969-50975, 2004.

Sriburi R, Jackowski S, Mori K, Brewer JW. XBP1: A link between the unfolded protein response, lipid biosynthesis and biogenesis of the endoplasmic reticulum. J Cell Biol 167: 35-41, 2004.
Commentary: Ron D, Hampton RY. Membrane biogenesis and the unfolded protein response. J Cell Biol 167:23-25, 2004. ER Stress: Meeting the Demand. http://stke.sciencemag.org/cgi/content/abstract/sigtrans;204/255/tw371

Ivey RA, Zhang Y-M, Virga KG, Hevener K, Lee RE, Rock CO, Jackowski S, Park H-W. The structure of the pantothenate kinase-ADP-pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulators and antimetabolites. J Biol Chem 270: 35622-35629, 2004.

Zweigner J, Jackowski S, Smith SH, van der Merwe M, Weber JR, Tuomanen EI. Bacterial inhibition of phosphatidylcholine synthesis: Determinant role in apoptosis in brain. J Exp Med 200:99-106, 2004.

Jackowski S, Rehg JE, Zhang Y-M, Wang J, Miller K, Jackson P, Karim MA. Disruption of CCTβ2 expression leads to gonadal dysfunction. Mol Cell Biol 24: 4720-4733, 2004.

Ramaswamy G, Karim MA, Murti KG, Jackowski S. PPARα controls the intracellular coenzyme A concentration via regulation of PANK1 gene expression. J Lipid Res 45: 17-31, 2004.

Ramos B, Lahti JM, Claro E, Jackowski S. Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells. Mol Pharmacol 64:502-511, 2003.

Rock CO, Park H-W, Jackowski S. Role of feedback regulation of pantothenate kinase (CoaA) in the control of coenzyme A levels in Escherichia coli. J Bacteriol 185:3410-3415, 2003.

Karim M, Jackson P, Jackowski S. Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase ß isoform. Biochim Biophys Acta 1633:1-12, 2003.

Ramos B, El Mouedden M, Claro E, Jackowski S. Inhibition of CTP:phosophocholine cytidylyltransferase by C2-ceramide and its relationship with apoptosis. Mol Pharmacol 62:1068-1075, 2002.

Jackowski S, Zhang YM, Price AC, White SW, Rock CO.  A missense mutation of the fabB (ß-ketoacyl-acyl carrier protein synthase I) gene confers thiolactomycin resistance to Escherichia coli. Antimicrob Agents Chemother 46:1246-1252, 2002.

Rock CO, Karim MA, Zhang YM, Jackowski S. The murine Pank1 gene encodes two differentially regulated pantothenate kinase isozymes. Gene 291:35-43, 2002.

Kwak B, Zhang YM, Yun M, Heath RJ, Rock C, Jackowski S, Park H-W. Structure and mechanism of CTP:phosphocholine Cytidylyltransferase (LicC) from Streptococcus pneumoniae. J Biol Chem 277:4343-4350, 2002.

Chiu CH, Jackowski S. Role of calcium-independent phospholipases (iPLA2 ) in phosphatidylcholine metabolism. Biochem Biophys Res Com 287:600-606, 2001.

Rock C, Heath RJ, Park H-W, Jackowski S. The licC gene of Streptococcus pneumoniae encodes a CTP:phosphocholine cytidylyltransferase. J Bacteriol 183:4927-4931, 2001.

Lykidis A, Jackson P, and Jackowski S. Lipid activation of CTP:phosphocholine cytidylyltransferase α: Characterization and identification of a second activation domain. Biochemistry 40:494-503 2001.

Lykidis A, Wang J, Karim M, and Jackowski S. Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway. J Biol Chem 276:2174-2179, 2001.

Last update: May 2009

 

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