Non-Therapeutic Protocol

HUSTLE: Long Term Effects of Hydroxyurea Therapy in Children with Sickle Cell Disease

Type of Protocol/Clinical Study

Associated Hematology Studies

Description

Many years of study have documented the severe effects of sickle cell disease.  Some of these effects include hemolysis (the break down of red blood cells), blockages in the blood vessels, and damage to the organ systems of the body. Hydroxyurea, which is given by mouth, is used to effectively prevent blockages in the blood vessels of patients with sickle cell disease. The hydroxyurea dosage varies and the responses of the body to this drug are not well understood.

This study will follow sickle cell patients being treated with hydroxyurea for a long period of time to evaluate the long-term cellular and molecular effects of the drug on the patients’ body. This study will consist of two patient groups.  One group will be made up of patients who have received hydroxyurea therapy before entering the study.  The second group will be made up of patients who have not received hydroxyurea before study entry.

Objectives

Eligibility

Only current St. Jude patients are eligible.

Principal Investigator

Kerri Nottage, MD

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