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Finding Cures. Saving Children.
Pharmaceutical Sciences
The outcome for children with cancer, HIV-1 infection, and other serious diseases continues to improve, largely through the improved use of medications. Failure of current therapies is at least partly due to less-than-optimal dosing of existing medications. For many medications, inherited differences in patients’ ability to metabolize, transport, and eliminate drugs and in the characteristics of their targets and receptors are significant determinants of therapeutic or adverse effects of medications.
In addition, the acquired genetic alterations of malignant cells may further influence the therapeutic index of medications. The faculty and trainees in Pharmaceutical Sciences develop preclinical models and integrate their work into translational clinical studies to elucidate the mechanisms responsible for interindividual differences in drug disposition and effects in the host and in the tumor.
Our pharmacogenetic research integrates high-throughput molecular analyses, functional genomics, pharmacokinetics, and pharmacodynamics to identify genetic determinants of drug effects in humans, with the long-term goal of optimizing drug therapy for individual patients.
Mary V. Relling, PharmD, chairs the Department of Pharmaceutical Sciences at St. Jude.
