A Study of Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic Leukemia (ALLR17)

For: acute lymphoblastic leukemia (ALL), lymphoblastic lymphoma

 
 

Phase I Study of Bevacizumab and Sorafenib Combined with Low Dose Cyclophosphamide in Patients with Refractory Solid Tumors and Leukemia

For: Recurrent or refractory solid tumors and leukemias

 
 

A Reduced Intensity Conditioning Regimen with CD3-Depleted Hematopietic Stem Cells to Improve Survival for Patients with Hematologic Malignancies Undergoing Haploidentical Stem Cell Transplantation

For: Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), Juvenile Myelomonocytic Leukemia (JMML), Paroxysmal Nocturnal Hemoglobinuria (PNH), Hodgkin lymphoma, Non-Hodgkin Lymphoma, Myelodysplastic Syndrome (MDS)

 
 

Stanford V Chemotherapy with Low-Dose Tailored-Field Radiation Therapy for Intermediate Risk Pediatric Hodgkin's Disease

For: Hodgkin lymphoma

 
 

Reduced duration Stanford V Chemotherapy with low-dost tailored-field radiation therapy for favorable risk pediatric Hodgkin lymphoma

For: Hodgkin lymphoma

 
 

Risk-Adapted Therapy for Pediatric Hodgkin's Disease

For: Hodgkin lymphoma

 
 

HLA - Nonidentical Stem Cell and Natural Killer Cell Transplantation for Children Less than 2 Years of Age with Hematologic Malignancies

For: Leukemias (high risk hematologic malignancies)

 
 

International Pediatric Adrenocortical Tumor Registry Data Collection

For: adrenocortical carcinoma

 
 

Phase II Study Incorporating Pegylated Interferon In The Treatment For Children With High-Risk Melanoma

For: Melanoma

 
 

Pilot Study of Haplo-Identical Natural Killer Cell Transplantation for Acute Myeloid Leukemia

For: Acute myeloid leukemia

 
 

Pilot Study of Expanded, Activated Haploidentical Natural Killer Cell Infusions for Non-B Lineage Hematologic Malignancies

For: Refractory or relapsed leukemia (AML, T-ALL, CML, JMML), T-cell lymphoma, and myelodysplastic syndrome

 
 

Pilot Study of Haploidentical Natural Killer Cell Infusions for Poor Prognosis Non-AML Hematologic Malignancies (NKHEM)

For: Non-acute myeloid leukemia hematologic malignancies

 
 

A Phase I Trial of the Combination of Oxaliplatin and Etoposide in Recurrent or Refractory Pediatric Solid Tumors and Lymphomas

For: Recurrent or refractory solid tumors or lymphomas

 
 

Phase I Study of the Use of Palifermin in Pediatric Research Participants Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

For: Hematologic malignancies

 
 

A Dose Finding Study (Phase I) of the Combination of ZD1839 (Iressa®) and Irinotecan (CamptosarTM) Given Orally in Children with Refractory Solid Tumors (AstraZeneca Protocol IRUSIRES0181)

For: Refractory solid tumors including glioblastoma, rhabdomyosarcoma, neuroblastoma, and osteosarcoma

 
 

Haploidentical hematopoietic stem cell transplantation using a novel Clofarabine containing conditioning regimen for patients with refractory hematologic malignancies

For: Acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic myeloid leukemia (CML), juvenile myelomonocytic leukemia (JMML), Hodgkin lymphoma, non-Hodgkin lymphoma, myelodysplastic syndrome (MDS)

 
 

A Pilot Pharmacokinetic, Pharmacodynamic, and Feasibility Study of Sorafenib in Combination with Cytarabine and Clofarabine in Patients with Refractory or Relapsed Hematologic Malignancies

For: Acute myeloid leukemia (AML), acute promyelocytic leukemia (APL), acute lymphoblastic leukemia (ALL), infantile leukemia (both AML and ALL), AML w/prior myelodysplastic syndrome (MDS), myelodysplastic / myeloproliferative neoplasms, biphenotypic leukemia

 
 

Protocol for the Study and Treatment of Patients with Intraocular Retinoblastoma

For: Retinoblastoma

 
 

Image Guided Radiotherapy for the Treatment of Musculoskeletal Tumors: A Phase II Prospective Evaluation of Radiation-related Treatment Effects

For: Ewing sarcoma; rhabdomyosarcoma; primitive neuroectodermal tumors (PNET) of the musculoskeletal system; soft tissue sarcomas; other bone sarcomas; chordoma

 
 

A Phase I Study of Unmodified Live Intranasal Sendai Virus Vaccine in Children and Toddlers: Assessment of Safety and Immunogenicity (Primary Vaccination Only)

For: Croup

 
 

Phase I Study of the Combination of Vandetanib and Dasatinib Administered During and After Radiation Therapy in Children with Diffuse Intrinsic Pontine Glioma

For: Diffuse intrinsic pontine glioma

 
 

A Phase I Trial of the Humanized Anti-GD2 Antibody (HU14.18K322A) in Children and Adolescents with Neuroblastoma or Melanoma

For: Neuroblastoma or melanoma

 
 

A Phase I/II Trial of a New Tyrosine Kinase Inhibitor (Tarceva; Erlotinib Hydrochloride; OSI-774) during and after Radiotherapy in the Treatment of Patients with Newly Diagnosed High-Grade Glioma and Unfavorable Low-Grade Glioma

For: Intracranial high-grade glioma and unfavorable low-grade glioma

 
 

Treatment of Patients with Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor (PNET), or Atypical Teratoid Rhabdoid Tumor (ATRT)

For: Medulloblastoma, supratentorial primitive neuroectodermal tumor (PNET), atypical teratoid rhabdoid tumor (ATRT), ependymoblastoma, pineoblastoma, central nervous system (CNS) neuroblastoma

 
 

Risk-Adapted Therapy for Children Less Than 3 Years of Age with Embryonal Brain Tumors, High-Grade Glioma, Choroid Plexus Carcinoma or Ependymoma

For: Embryonal brain tumors, choroid plexus carcinoma or ependymoma

 
 

Allogeneic Bone Marrow Transplantation for Children with Solid Malignancies

For: Solid tumors, Lymphoma

 
 

A Phase III Randomized Clinical Trial to Compare Standard Therapy with Alternative Therapy for the Prevention of Secondary Stroke and the Management of Iron Overload in Pediatric Subjects with Sickle Cell Anemia and Previous Stroke

For: Sickle cell anemia

 
 

Total Therapy Study XVI for Newly Diagnosed Patients with Acute Lymphoblastic Leukemia

For: Acute Lymphoblastic Leukemia

 

Non St. Jude Protocols

 

The Optimized Treatment that Includes or Omits NRTIs (OPTIONS) Trial: A Randomized Strategy Study for HIV-1 Infected Treatment-Experienced Subjects Using the cPSS to Select an Effective Regimen

For: Infectious Disease

 
 

A Phase II Study of Trabectedin in Children with Recurrent Rhabdomyosarcoma, Ewing Sarcoma, or Non-Rhabdomyosarcoma Soft Tissue Sarcomas

For: Rhabdomyosarcoma, Ewing sarcoma, non-rhabdomyosarcoma soft tissue sarcomas

 
 

A Phase I Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (Bay 43-9006, NSC#724772, IND#69896) in Children with Refractory Solid Tumors or Refractory Leukemias (ADVL0413)

For: All Leukemias, Solid Tumors

 
 

A Phase I Study of VEGF Trap (NSC# 724770, IND# 100137) in Children with Refractory Solid Tumors

For: All Solid Tumors, CNS Malignancies

 
 

Killer Immunoglobulin-Like Receptor (KIR) Incompatible Hematopoietic Cell Transplantation (HCT) for Refractory and Relapsed Acute Myelogenous Leukemia (AML) in Children: A Children’s Oncology Group (COG) Study (AAML05P1)

For: Refractory and relapsed acute myelogenous leukemia (AML)

 
 

A Pilot Study of Lestaurtinib (CEP-701) in Combination with Chemotherapy in Young patients with Relapsed or Refractory FLT3-mutant Acute Myeloid Leukemia (AAML06P1)

For: Relapsed or refractory FLT3-mutant acute myeloid leukemia

 
 

Perinatal Neuroblastoma: Expectant Observation - A Children's Oncology Group Pilot Study

For: Neuroblastoma

 
 

(PACTG 1026S) Pharmacokinetic Properties of Antiretroviral Drugs During Pregnancy

For: HIV Infection

 
 

A Phase I Study of the Safety, Tolerance, and Pharmacokinetics of Tenofovir Disoproxil Fumarate (TDF) and the Combination of TDF Plus Emtricitabine in HIV-1 Infected Pregnant Women and Their Infants

For: HIV (Human Immunodeficiency Virus) infection in pregnant women

 
 

Preservation and Expansion of T-cell Subsets Following HAART De-intensification to Atazanavir/ritonavir (ATV/r) in Adolescents and Young Adults with CD4+ T Cells > 350 and HIV RNA < 100,000 Initiating HAART

For: Human Immunodeficiency Virus (HIV)

 
 

A Randomized, Double-Blind, Placebo-Controlled Trial of the Safety and Effectiveness of Vitamin D Supplement to Improve Tubular Reabsorption of Phosphate and Decrease Bone Turnover in Adolescents and Young Adults with HIV Infection Being Treated with Antiretroviral Therapy Containing Tenofovir Compared to Those Being Treated with Antiretroviral Therapy Not Containing Tenofovir

For: Human Immunodeficiency Virus (HIV)

 
 

A phase I, multi-center, dose escalation study of CAT-8015 in children, adolescents and young adults with refractory CD22+ acute lymphoblastic leukemia (ALL), or non-Hodgkin’s Lymphoma (NHL) (CAT-8015-1004)

For: acute lymphoblastic leukemia (ALL), non-Hodgkin’s lymphoma (NHL), including lymphoblastic lymphoma, Burkitt’s lymphoma, and large cell lymphoma

 
 

A Phase I/II Dose Escalation Study of Clofarabine in Combination with Etoposide and Cyclophosphamide in Pediatric Patients with Refractory or Relapsed Acute Leukemias

For: Refractory or relapsed acute leukemia

 
 

A Phase II Study of Conformal Radiotherapy in Patients with Low-Grade Gliomas (ACNS0221)

For: Central Nervous System Tumors

 
 

Phase III Radiotherapy Alone vs. Chemotherapy Followed by Response-based Radiotherapy for Newly Diagnosed Primary CNS Germinoma (ACNS0232)

For: Germinoma

 
 

Cilengitide (EMD 121974) (IND# 59073) in Recurrent or Progressive and Refractory Childhood High-Grade Glioma

For: Gliomas

 
 

A Phase III Study of Reduced Therapy in the Treatment of Children with Low and Intermediate Risk Extracranial Germ Cell Tumors (AGCT0132)

For: Germ cell tumor

 
 

Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors with Paclitaxel, Ifosfamide and Carboplatin

For: Germ Cell Tumor

 
 

A Randomized Phase II Study of Bortezomib (PS-341), Velcade, IND 58443, NSC 681239) in Combination with Ifosfamide/Vinorelbine in Pediatric Patients with Relapsed/Refractory Hodgkin Disease

For: Hodgkin lymphoma

 
 

An International, Randomized, Controlled Trial of Immune-Tolerance Induction

For: hemophilia A

 
 

Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma

For: Neuroblastoma

 
 

A Phase III Trial of Treatment of Advanced-Stage Anaplastic Large Cell Lymphoma (ALCL) with Standard APO (Doxorubicin, Prednisone, Vincristine) versus Consolidation with a Regimen Including Vinblastine

For: non-Hodgkin lymphoma, anaplastic large cell lymphoma

 
 

A Study to Determine the Activity of SCH 717454 in Subjects with Osteosarcoma or Ewing’s Sarcoma that has Relapsed after Standard Systemic Therapy (SCH Protocol: PO4720) (US IND BB-100343)

For: Solid tumors, osteosarcoma, Ewing sarcoma

 
 

A Phase I Pharmacokinetic Optimal Dosing Study of Intraventricular Topotecan for Children with Neoplastic Meningitis

For: Neoplastic meningitis

 
 

A Phase I Clinical Trial of AZD2171 In Children With Recurrent or Progressive Central Nervous Systems (CNS) Tumors

For: Recurrent or Progressive Central Nervous System (CNS) Tumors

 
 

Phase II study of Bevacizumab plus Irinotecan (Camptosar) in Children with Recurrent, Progressive, or Refractory Malignant Gliomas, Diffuse/Intrinsic Brain Stem Gliomas, Medulloblastomas, Ependymomas and Low Grade Gliomas

For: Gliomas

 
 

Phase I and Pharmacokinetic Study of Enzastaurin (LV317615) in Children and Adolescents with Refractory Primary CNS Tumors

For: Brain tumors

 
 

A Phase 1 study of MK-0752 in Pediatric Patients with Recurrent or Refractory CNS Malignancies

For: Brain tumors

 
 

A Phase I Pharmacokinetic and Safety Study in Children with Recurrent or Refractory Medulloblastoma to Identify a Pharmacokinetic Based Dose for GDC-0449

For: Brain tumors

 
 

Treatment of Childhood Nasopharyngeal Carcinoma with Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy

For: Nasopharyngeal carcinoma

 
 

Treatment of Adrenocortical Tumors with Surgery plus Lymph Node Dissection and Multiagent Chemotherapy

For: Adrenocortical tumors

 
 

Treatment of High Risk Renal Tumors

For: Solid Tumor: Wilms tumor, renal tumor

 
 

Treatment for Very Low, Low and Standard Risk Favorable Histology Wilms Tumor

For: Wilms Tumor

 
 

A Phase II Study of Sulindac and Tamoxifen in Patients with Desmoid Tumors that are Recurrent or Not Amenable to Standard Therapy (ARST0321)

For: Desmoid Tumor (also known as fibromatosis)

 
 

Vincristine, Dactinomycin, and Lower Doses of Cyclophosphamide with or without Radiation Therapy for Patients with Newly Diagnosed Low-Risk Embryonal/Botryoid/Spindle Cell Rhabdomyosarcoma

For: Rhabdomyosarcoma (embryonal/botryoid/spindle cell subtypes)

 
 

Risk-Based Treatment for Pediatric Non-Rhabdomyosarcoma Soft Tissue Sarcomas

For: Non-rhabdomyosarcoma soft tissue sarcomas

 
 

Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS)

For: Rhabdomyosarcoma

 
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