Charles G. Mullighan, MBBS(Hons), MSc, MD

Charles G. Mullighan, MBBS(Hons), MSc, MD

Member, St. Jude Faculty

Departments

Pathology

Contact Information

Charles Mullighan, MBBS(Hons), MSc, MD
Pathology
MS 342, Room D-4047E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: charles.mullighan@stjude.org
Phone: (901) 595-3387
FAX: (901) 595-5947

Education

MBBS(Hons) - University of Adelaide (1993)
MSc - University of London (1997)
MD - University of Adelaide (1998)
Fellowship of the Royal College of Pathologists of Australasia – 2004
Fellowship of the Royal Australasian College of Physicians - 2004


Honors & Awards


Research Interests


Selected Publications

A full list of publications can be found at http://www.ncbi.nlm.nih.gov/pubmed/?term=mullighan.

Ma X, Edmonson M, Yergeau D, Muzny D, Hampton OA, Rusch M, Song G, Easton J, Harvey RC, Wheeler DA, Ma J, Doddapaneni H, Vadodaria B, Wu G, Nagahawatte P, Carroll WL, Chen I-M, Gastier-Foster JM, Relling MV, Smith MA, Devidas M, Guidry Auvil JM, Downing JR, Loh ML, Willman CL, Gerhard DL, Mullighan CG*, Hunger SP* and Zhang J*. The Rise and Fall of Subclones from Diagnosis to Relapse in Pediatric B-progenitor Acute Lymphoblastic Leukemia. Nat Commun 2015, In press. *co-corresponding.

Andersson AK, Ma J, Wang J, Chen X, Larson-Gedman A, Dang J, Nakitandwe J, Holmfeldt L, Parker M, Easton J, Huether R, Kriwacki R, Rusch M, Wu G, Mulder H, Raimondi S, Pounds S, Guolian K, Shi L, Becksfort, Gupta P, Payne-Turner D, Vadodaria B, Manne J, Song G, Edmonson M, Nagawatte P, Wei L, Cheng C, Pei D, Sutton R, Venn NC, Chetcuti A, Rush A, Catchpoole D, Heldrup J, Fioretos T, Lu C, Ding L, Pui C-H, Shurtleff S, Gruber TA, Mullighan CG, Mardis ER, Wilson RK, Zhang J, Downing JR, for the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project. The landscape of somatic mutations in Infant MLL rearranged acute lymphoblastic leukemias. Nat Genet 2015, In press. doi: 10.1038/ng.3230.

Maude SL, Dolai S, Delgado-Martin C, Vincent T, Robbins A, Selvanathan A, Ryan T, Hall J, Wood AC, Tasian SK, Hunger SP, Loh ML, Mullighan CG, Wood BL, Hermiston ML, Grupp SA, Lock RB, Teachey DT. Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia. Blood 25(11):1759-1767, 2015.

Perez-Andreu V, Roberts KG, Xu H, Smith C, Zhang H, Yang W, Harvey RC, Payne-Turner D, Devidas M, Cheng I-M, Carroll WL, Heerema NA, Carroll AJ, Raetz EA, Gastier-Foster JM, Marcucci G, Bloomfield CD, Mrozek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Rowe JM, Luger SM, Tallman MS, Dean M, Burchard EG, Yue F, Wang Y, Pui C-H, Jeha S, Relling MV, Evans WE, Gerhard DS, Loh ML, Willman CL, Hunger SP, Mullighan CG*, Yang JJ*. A Genome-wide Association Study of Susceptibility to Acute Lymphoblastic Leukemia in Adolescents and Young Adults. Blood 125(4):680-6, 2015. doi: 10.1182/blood-2014-09-595744. *co-corresponding.

Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC, Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT Sicinski P. Cyclin C is a haploinsufficient tumor suppressor. Nat Cell Biol 16(11):1080-91, 2014. doi: 10.1038/ncb3046.

Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang Y-L, Pei D, McCastlain K, Song G, Ma J, Becksfort J, Rusch M, Chen S-C, Easton J, Cheng J, Wen J, Santiago-Morales N, Iacobucci I, Valentine M, Cheng C, Paugh SW, Devidas M, Chen I-M, Reshmi S, Hedlund E, Gupta P, Nagahawatte P, Wu G, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Raetz EA, Guidry Auvil J, Smith MA, White D, Hughes TP, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui C-H, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Loh ML, Downing JR, Hunger SP, Willman C, Zhang J, Mullighan CG. Targetable kinase activating lesions in Philadelphia chromosome-like acute lymphoblastic leukemia. N Engl J Med 371(11):1005-15, 2014.

Ntziachristos P, Tsirigos A, Welstead G, Trimarchi T, Bakogianni S, Xu L, Loizou E, Holmfeldt L, Strikoudis A, King B, Mullanders J, Becksfort J, Nedjic J, Paietta E, Tallman MS, Rowe JM, Satoh T, Kruidenier L, Prinjha R, Akira S, Van Vlierberghe P, Ferrando AA, Jaenisch R, Mullighan CG*, Aifantis I*. Contrasting roles for histone 3 lysine 27 demethylases in acute lymphoblastic leukemia. Nature 514(7523):513-7, 2014. *co-corresponding.

Roberts KG, Pei D, Campana D, Payne-Turner D, Li Y, Cheng C, Sandlund JT, Jeha S, Easton J, Becksfort J, Zhang J, Coustan-Smith E, Raimondi SC, Leung W, Relling MV, Evans WE, Downing JR, Mullighan CG*, Pui CH*. Outcome of Children with BCR-ABL1-like Acute Lymphoblastic Leukemia Treated with Risk-directed Therapy Based on the Levels of Minimal Residual Disease. J Clin Oncol 32(27)3012-20, 2014. *equal contribution.

Zhang J, Huether R, Dong L, Chen X, Wu G, Parker M, Wei L, Ma J, Edmonson M, Hedlund E, Rusch M, Shurtleff S, Mulder H, Boggs K, Vadodaria B, Cheng J, Yergeau D, Song G, Becksfort J, Cai Z, Lemmon G, Dang J, Weber C, Walsh M, Larson Gedman A, Faber Z, Easton J, Gruber T, Kriwacki R, Partridge J, Ding L, Wilson R, Mardis E, Mullighan CG, Gilbertson R, Baker S, Zambetti G, Ellison D, Downing JR. The landscape of somatic mutations in epigenetic regulators across 1000 pediatric cancer genomes. Nature Commun 5:3630, 2014. doi: 10.1038/ncomms4630.

Treanor LM, Zhou S, Janke L, Churchman ML, Ma Z, Lu T, Chen S-C, Mullighan CG, Sorrentino BP. Interleukin 7 receptor mutants initiate early T-cell precursor leukemia in murine thymocyte progenitors with multipotent potential. J Exp Med 211(4):701-13, 2014. doi: 10.1084/jem.20122727.

Waibel M, Solomon VS, Knight DA, Ralli RA, Kim SK, Banks KM, Vidacs E, Virely C, Sia KC, Bracken LS, Collins-Underwood R, Drenberg C, Ramsey LB, Meyer SC, Takiguchi M, Dickins RA, Levine R, Ghysdael J, Dawson MA, Lock RB, Mullighan CG, Johnstone RW. Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors. Cell Rep 5(4):1047-59, 2013. doi: 10.1016/j.celrep.2013.10.038.

Perez-Andreu V, Roberts KG, Harvey RC, Cheng C, Pei D, Gastier-Foster J, Yang W, Xu H, Shuyu E, Lim JY, Chen I-M, Fan Y, Devidas M, Borowitz MJ, Neale G, Burchard EG, Torgerson DG, Klussman FA, Villagran CRN, Winick NJ, Camitta BM, Carroll WL, Larsen E, Bowman WP, Loh M, Dean M, Bhojwani D, Pui C-H, Evans WE, Relling MV, Hunger SP, Willman CL, Mullighan CG, Yang JJ. Inherited GATA3 Genetic Variants are Associated with Ph-like Childhood Acute Lymphoblastic Leukemia and Risk of Relapse. Nat Genet 45:1494-8, 2013.

Jaffe JD, Wang Y, Chan HM, Zhang J, Huether R, Kryukov GV, Bhang HV, Taylor JE, Hu M, Englund NP, Yan F, Wang Z, McDonald ER, Wei L, Ma L, Easton J, Yu Z, deBeaumount R, Gibaja V, Venkatesan K, Schlegel R, Sellers WR, Keen N, Liu J, Caponigro G, Barretina J, Cooke V, Mullighan CG, Carr SA, Downing JR, Garraway LA, Stegmeier F. Global Chromatin Profiling identifies NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet 45:1386-91, 2013. doi: 10.1038/ng.2777.

Shah S*, KA Schrader*, Waanders E*, Timms A*, Vijai J*, Miething C*, Wechsler J, Yang J, Hayes J, Klein RJ, Zhang J, Wei L, Wu G, Rusch M, Nagahawatte P, Ma J, Chen S-C, Song G, Meyers P, Bhojwani D, Jhanwar S, Maslak P, Fleisher M, Littman J, Offit L, Rau-Murthy R, Fleischut MH, Gao X, Manschreck C, Kitzing T, Murty VV, Raimondi S, Kuiper RP, Simons A, Schiffman JD, Onel K, Plon SE, Wheeler D, Ritter D, Ziegler DS, Tucker K, Sutton R, Chenevix-Trench G, Li J, Huntsman DG, Hansford S, Senz J, Walsh T, Lee M, Hahn CN, King M-C, Lipkin SM, Lo SM, Levine RL, Viale A, Socci ND, Nathanson KL, Daly M, Scott HS, Lowe SW, Downing JR, Altshuler D, Sandlund JT, Horwitz MS^, Mullighan CG^, Offit K^. Identification of a recurrent germline PAX5 mutation and susceptibility ot pre-B acute lymphoblastic leukemia. Nat Genet 45(10):1226-31, 2013. *co-contributing, ^co-corresponding .

Figueroa ME, Chen S-C, Andersson AK, Phillips LA, Li Y, Sotzen J, Kundu M, Downing JR, Melnick AM, Mullighan CG. Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia. J Clin Invest 123(7):3099-111, 2013.

Weston BW, Hayden MA, Roberts KG, Bowyer S, Hsu J, Fedoriw G, Rao K, Mullighan CG. Tyrosine kinase inhibitor therapy induces remission in a patient with refractory EBF-PDGFRB positive acute lymphoblastic leukemia. J Clin Oncol 31(25):e413-6, 2013. doi: 10.1200/JCO.2012.47.6770.

Holmfeldt L, Wei L, Diaz-Flores E, Walsh M, Zhang J, Ding L, Payne-Turner D, Churchman M, Andersson A, Chen S-C, McCastlain K, Becksfort J, Ma J, Wu G, Patel SN, Heatley SL, Phillips LA, Song G, Easton J, Parker M, Chen X, Rusch M, Boggs K, Vadodaria B, Hedlund E, Drenberg C, Baker S, Pei D, Cheng C, Lu C, Fulton RS, Fulton L, Tabib Y, Dooling DJ, Ochoa K, Minden M, Lewis ID, To LB, Marlton P, Roberts AW, Raca G, Stock W, Neale G, Drexler HG, Dickins RA, Ellison DW, Shurtleff SA, Pui C-H, Ribeiro RC, Devidas M, Carroll AJ, Heerema NA, Wood B, MJ Borowitz, Gastier-Foster JM, Raimondi SC, Mardis ER, Wilson RK, Downing JR, Hunger SP, Loh ML, Mullighan CG. The Genomic Landscape of Hypodiploid acute lymphoblastic leukemia. Nat Genet 45:242-52, 2013.

Kreso A, O'Brien CA, van Galen P, Gan O, Notta F, Brown AM, Ng K, Ma J, Wienholds E, Dunant C, Pollett A, Gallinger S, McPherson J, Mullighan CG, Shibata D, Dick JE. Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer. Science 339:543-8, 2013.

Hussin J, Sinnett D, Casals F, Idaghdour Y, Bruat V, Saillour V, Healy J, Grenier JC, De Malliard T, Spinella JF, Lariviere M, Busche S, Gibson G, Andersson A, Holmfeldt L, Ma J, Wei L, Zhang J, Andelfinger G, Downing J, Mullighan C, Awadalla P. Rare allelic forms of PRDM9 associated with childhood leukemogenesis. Genome Res 23:419-30, 2013. doi: 10.1101/gr.144188.112.

Loh ML, Zhang J, Harvey RC, Roberts KG, Payne-Turner DL, Kang H, Wu G, Chen X, Becksfort J, Edmonson M, Buetow KE, Carroll WL, Chen I, Wood BL, Borowitz MJ, Devidas M, Gerhard DS, Bowman WP, Larsen EC, Winick NC, Raetz E, Smith M, Downing JR, Willman CL*, Mullighan CG*, Hunger SP* Tyrosine Kinome Sequencing of Pediatric Acute Lymphoblastic Leukemia: A Report from The Children’s Oncology Group TARGET Project. Blood 121:485-8, 2013. doi: 10.1182/blood-2012-04-422691. *co-corresponding authors.

Roberts KG*, Morin RD*, Zhang J, Hirst M, Zhao Y, Su X, Payne-Turner D, Chen X, Harvey RC, Kasap C, Yan C, Churchman M, Chen S-C, Becksfort J, Finney R, Teachey DT, Maude SL, Tse K, Moore R, Jones S, Mungall K, Birol I, Edmonson MN, Hu Y, Buetow KE, Chen I-M, Carroll WL, Wei L, Ma J, Larsen E, Shah NP, Devidas M, Reaman G, Smith M, Evans WE, Paugh SW, Grupp SA, Pui C-H, Gerhard DS, Downing JR, Willman CL, Loh M, Hunger SP, Marra M, Mullighan CG. Novel genetic alterations activating kinase and cytokine receptor signaling in high risk acute lymphoblastic leukemia. Cancer Cell 22:153-66, 2012.

Zhang J, McEvoy J, Flores-Otero J, Ding L, Chen X, Wilson M, Wu G, Wang J, Zhang J, Brennan R, Rusch M, Ma J, Ulyanov A, Easton J, Barbato M, Shurtleff S, Mullighan CG, Lei W, Neale G, Pounds S, Mukatira S, Rodriguez-Galindo C, McGoldrick D, Gupta P, Zhao D, Alford D, Espy S, Obenauer J, Qaddoumi I, Lu C, Fulton RS, Fulton L, Hong X, Harris CH, Dooling DJ, Ochoa K, Johnson K, Haik B, Naeve C, Ley TJ, Mardis ER, Dalton J, Ellison D, Wilson RK, Downing JR, Dyer MA, for the St. Jude Children’s Research Hospital - Washington University Pediatric Cancer Genome Project. A Novel Retinoblastoma Therapy from Genomic and Epigenetic Analyses. Nature 481:329-34, 2012.

Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Wei L, Ulyanov A, Becksfort J, Chen S-C, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Evans WE, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert, K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Pui C-H, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481:157-63, 2012.

Zhang J*, Mullighan CG*, Harvey RC, Wu G, Chen X, Edmonson M, Buetow KH, Carroll WL, Cheng I-M, Devidas M, Gerhard DS, Loh ML, Reaman GH, Relling MV, Camitta BM, Bowman WP, Smith MA, Willman CL, Downing JR, Hunger SP. RAS signaling, B-cell development, TP53/RB1, and JAK signaling pathways are frequently mutated in high-risk B-precursor childhood acute lymphoblastic leukemia. Blood 118:3080-7, 2011. *co-first author.

Wang J, Mullighan CG, Easton J, Roberts S, Ma J, Rusch MC, Chen K, Harris CC, Ding L, Heatley SL, Holmfeldt L, Payne-Turner D, Fan X, Wei L, Zhao D, Obenauer J, Naeve C, Mardis ER, Wilson RK, Downing JR and Zhang J, for the St Jude Children’s Research Hospital - Washington University Pediatric Cancer Genome Project. CREST: an algorithm that maps structural variation with base-pair resolution. Nat Methods 8:652-4, 2011.

Mullighan CG*, Zhang J*, Kasper LH, Lerach S, Payne-Turner D, Phillips LAA, Ma J, Buetow, KH, Pui C-H, Brindle P, Downing JR. CREBBP mutations in relapsed acute lymphoblastic leukemia. Nature 471:189-95, 2011. *corresponding author and co-first author.

Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Ma J, Rossi D, Mullighan CG, Rabadan R, Gaidano G, Brindle P, Dalla-Favera R. Inactivating mutations in acetyl-transferase genes in B-cell non-Hodgkin lymphoma. Nature 471:189-95, 2011.

Notta F*, Mullighan CG*, Wang JCY, Poeppl A, Doulatov S, Phillips LA, Ma J, Minden MD, Downing JR, Dick JE. Evolution of human BCR-ABL1 lymphoblastic leukemia-initiating cells. Nature 469:362-7, 2011 *co-first author.

Mullighan CG*, Collins-Underwood JR, Phillips LAA, Loudin ML, Liu W, Zhang J, Ma J, Coustan-Smith E, Harvey RC, Willman CL, Mikhail FM, Meyer J, Carroll AJ, Williams RT, Cheng J, Heerema NA, Basso G, Pession A, Pui C-H, Raimondi SC, Hunger SP, Downing JR, Carroll WL, Rabin KR. Rearrangement of CRLF2 in B-progenitor and Down syndrome associated acute lymphoblastic leukemia. Nat Genet 41:1243-1246, 2009. *corresponding author.

Mullighan CG, Zhang J, Harvey RC, Collins-Underwood JR, Schulman BA, Phillips LAA, Tasian SK, Loh ML, Su X, Liu W, Devidas M, Atlas SR, Chen I-M, Clifford RJ, Gerhard DS, Carroll WL, Reaman GH, Smith M, Downing JR, Hunger SP and Willman CL. JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 106:9414-8, 2009.

Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D, Cheng C, Su X, Rubnitz JE, Basso G, Biondi A, Pui CH, Downing JR, Campana D. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol 10:147-56, 2009.

Mullighan CG, Su X, Zhang J, Radtke I, Phillips LA, Miller CB, Ma J, Liu W, Cheng C, Schulman BA, Harvey RC, Chen I-M, Clifford RJ, Carroll WL, Reaman G, Bowman WP, Devidas M, Gerhard DS, Yang W, Relling MV, Shurtleff SA, Campana D, Borowitz M, Pui C-H, Smith M, Hunger SP, Willman C, Downing JR, and the Children's Oncology Group. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 360:470-480, 2009.

Mullighan CG, Phillips LA, Su X, Ma J, Miller CB, Shurtleff SA, Downing JR. Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science 322:1377-80, 2008.

Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, White D, Hughes TP, Le Beau MM, Pui C.-H., Relling MV, Shurtleff, SA, Downing JR. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 453:110-4, 2008.

Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui C-H, Relling MV, Evans WE, Shurtleff SA, Downing JR Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446:758-64, 2007.


Last updated: September 2013