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Non-Therapeutic Protocol

PBSCRV: Peripheral Blood Stem Cells Obtained from Normal Volunteers for Studying Retroviral Vector Mediated Gene Transfer into Primitive Hematopoietic Cells and Vector Mediated Transgene Expression in Mature Hematopoietic Lineages

Type of Protocol/Clinical Study

Associated Stem Cell Transplant Studies, Supportive Studies: Genetics

Description

Stem cells are young cells that are produced in the bone marrow. Bone marrow is a spongy tissue that is located in the long bones of the body. Stem cells as they mature become several different types of blood cells - the white blood cells fight infection, the red blood cells carry oxygen, and platelets help the blood to clot. Stem cells can be found in the circulating blood system.

Healthy adults participating in this study will be given a medication known as growth factor. Growth factor exists naturally in the body. Administering growth factor to the participant will increase the number of stem cells present in the circulating blood system. These circulating stem cells will be collected from the participant using a procedure known as apheresis.

Apheresis is a process that uses a machine to draw blood from the vein in one arm. The blood passes through a machine that removes a specific blood component. The stem cells will be selectively removed and the blood will be returned to the participant through a vein in the other arm.  The body of normal healthy adults is able to replenish the stem cells within a couple of weeks.

The stem cells that are collected will be used to study possible ways of correcting problems that occur within the genes of the cells. The goal is to use the knowledge gained through this research to treat patients who have a blood disease that is due to a defective gene. 

Objectives

Eligibility

Principal Investigator

Arthur W. Nienhuis, MD

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.