Diagnostic Assay for Antibiotic Tolerance (SJ-01-0022)


Technology Name
(St. Jude Reference #)
Diagnostic Assay for Antibiotic Tolerance (SJ-01-0022)
Description Methods for identifying antibiotic tolerant bacteria and subjects infected with such bacteria, are provided. Once identified, alternative treatments can be used to inhibit such infections. The methods are based on the identification of allelic variations in the bacterial vex2, pep27 and vncS genes associated with antibiotic tolerance, especially to penicillin and vancomycin. Test kits and components useful for performing such methods, particularly including custom oligonucleotide primers, are also provided.
Related Reagents Primers for identifying allelic variations are available
Keywords Antibiotic tolerance, vex2, pep27, vncS, penicillin, vancomycin
Granted Patents or Published Applications U.S. Patent No. 6,623,931
Related Scientific References Rodriguez CA, et al., “Tolerance to vancomycin in pneumococci:  detection with a molecular marker and assessment of clinical impact.” J Infect Dis 190(8):1481-1487 (Oct 15, 2004)
Licensing Opportunities We are currently seeking licensing opportunities in all fields for the development of this technology.


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Last update: September 2008