Leukemia / Lymphoma Program Featured Research

A list of recent featured research from the Leukemia / Lymphoma team.

 
10/27/2009
Perilous precursors

St. Jude scientists identify a completely new and deadly subtype of leukemia that arises from early T-cell precursors. The discovery allows early detection and therapeutic intervention to improve the outcome for children with this form of drug-resistant leukemia.

 
 
10/19/2009
New chromosomal abnormality identified in leukemia associated with Down syndrome

Researchers identified a new chromosomal abnormality in acute lymphoblastic leukemia (ALL) that appears to work in concert with another mutation to give rise to cancer. This latest anomaly is particularly common in children with Down syndrome.

 
 
08/17/2009
Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia

Scientists at St. Jude Children’s Research Hospital have identified inherited variations in two genes that account for 37 percent of childhood acute lymphoblastic leukemia (ALL), including a gene that may help predict drug response.

 
 
07/27/2009
Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps, according to new findings from St. Jude Children’s Research Hospital.

 
 
06/24/2009
Acute lymphoblastic leukemia, the most common childhood cancer, is curable without preventive cranial radiation

Childhood acute lymphoblastic leukemia (ALL) can be successfully treated using a carefully personalized chemotherapy regimen without cranial radiation, investigators at St. Jude Children's Research Hospital have found. Such radiation of the brain was once a standard ALL treatment to prevent recurrence of the leukemia in the central nervous system (CNS).

 
 
06/02/2009
Mutant genes identified in high-risk childhood leukemias

A research team has pinpointed a new class of gene mutations, which identify cases of childhood acute lymphoblastic leukemia (ALL) that have a high risk of relapse and death.

 
 
04/14/2009
St. Jude Acute Lymphoblastic Leukemia Team recognized with prestigious science award

Scientists at St. Jude Children’s Research Hospital who represent the interdisciplinary team studying acute lymphoblastic leukemia (ALL) have been recognized by the American Association for Cancer Research (AACR) with the AACR Team Science Award.

 
 
02/19/2009
Pinpointing a high-risk leukemia promises better treatment

For the first time, St. Jude researchers have identified a subtype of acute T-lymphoblastic leukemia (T-ALL) that is resistant to standard chemotherapy. They are planning to use this new insight to diagnose the disease in children with the subtype and to use bone marrow transplants to more effectively treat the disease.

 
 
02/03/2009
St. Jude finds more than 100 gene variations linked with response to leukemia treatment

Scan of thousands of inherited genetic changes reveal specific variations linked to treatment failure and the fate of chemotherapy drugs in the body for children with acute lymphoblastic leukemia.

 
 
01/09/2009
Gene abnormality found to predict childhood leukemia relapse

Scientists have identified genetic mutations that predict a high likelihood of relapse in children with acute lymphoblastic leukemia (ALL).

 
 
12/05/2008
St. Jude identifies genomic causes of a certain type of leukemia relapse

Scientists at St. Jude have identified distinctive genetic changes that cause relapse in children with acute lymphoblastic leukemia (ALL).

 
 
08/18/2008
Protective “suicide protein” found to be thwarted in lymphoma

St. Jude investigators have found that a protein called Puma, which normally protects the body by triggering cancer cells to commit suicide through a process called apoptosis, is suppressed in Burkitt lymphoma.

 
 
07/17/2008
Vigilant care saves children with early leukemia complications

The supportive care of children suffering from early complications of acute myeloid leukemia (AML) has greatly reduced their death rate, according to a new St. Jude study.

 
 
04/15/2008
Childhood leukemia: tackling the challenge of CNS relapse

Clinicians have achieved a gratifyingly high success rate in treating childhood leukemias — a major challenge is to improve treatment of central nervous system (CNS) leukemia.

 
 
02/07/2008
St. Jude researchers identify key genetic trigger of AML

A gene called N-Myc leads a double life in certain white blood cells when it is overexpressed, helping to trigger a cancer called acute myeloid leukemia (AML) under some conditions while triggering apoptosis, or cell suicide, under other conditions, according to results of a study done by St. Jude investigators.

 
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