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Associated Infectious Diseases Studies : Human Immunodeficiency Virus (HIV)
HIV infected children, youth and adults have lower BMD (bone marrow density) than would be expected for healthy people of similar age, weight and race. As the majority of perinatally HIV infected US children are entering or in adolescence, the potential for HIV-related impaired BMD during the adolescent peak of bone mass acquisition is of particular concern.
This is is a pilot study to assess the effect of 48 weeks of alendronate therapy on BMD in HIV-infected youth with low BMD. It is clear that older adults with low bone density have a higher risk of spinal fracture or other broken bone. Many experts believe that children and youth with low bone density are also at risk of a spinal fracture or other broken bone over time. There are some things that can keep or make bones stronger, like getting enough vitamin D, calcium, and exercise and not smoking cigarettes. There are also drugs, like alendronate, that work by stopping bones from losing the minerals that make them strong.
Alendronate (brand name Fosamax®) is a drug approved by the Food and Drug Administration (FDA) to treat and prevent low bone density and prevent broken bones in adults. This study is being done to see if alendronate can safely improve bone density more than vitamin D, calcium and exercise alone in children and youth with HIV infection who already have low bone density.
Aditya Gaur, MD
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.