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Research
| Technology Name (St. Jude Reference #) |
Diagnosis and Treatment of Drug Resistant Leukemia (SJ-04-0001) |
| Description | This technology arose from an analysis of differences in gene expression between drug-sensitive and drug-resistant leukemia cells. Differentially expressed genes act as biomarkers for drug resistant leukemia, and further serve as molecular targets for drugs useful in treating drug resistant leukemia. Methods are provided for diagnosing drug resistant leukemia and for selecting an appropriate therapy. Screening methods are also provided for identifying compounds useful in treating drug-resistant leukemia. |
| Keywords | Gene expression profiling, drug resistance, leukemia |
| Granted Patents or Published Applications | International Application Pub. No. WO 2005/118865 published December 15, 2005 |
| Related Scientific References | Holleman et al., “Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment”, N. England J. Medicine 351(6): 533-542 (Aug. 2004) |
| Licensing Opportunities | We are currently seeking licensing opportunities in all fields for the development of this technology. |
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: January 2006
