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(St. Jude Reference #)
|Ozz, A Protein That Regulates Development and Function of Muscle Cells (SJ-99-0010)|
|Description||Ozz is a muscle-specific adapter protein of an E3 ligase complex that ubiquitinates ß-catenin and may target ß-catenin and MyHCemb for degradation during myogenesis. Deregulation of Ozz activity in developing and/or differentiating muscle fibers may influence cellular homeostasis and in turn result in heart or skeletal muscle myopathies. The Ozz gene overlaps with the transcriptional unit of the protective protein/cathepsin A (PPCA) gene, which is mutated in the human lysosomal disease galactosialidosis. It is possible that a mutation in the PPCA gene may affect expression of Ozz.|
|Granted Patents or Published Applications||U.S. Patent Nos. 7,074,908 and 7,425,615|
|Related Scientific References||Tommaso Nastasi, et. al., "Ozz-E3, A Muscle-Specific Ubiquitin Ligase, Regulates β-Catenin Degradation during Myogenesis" Developmental Cell, Vol 6, 269-282, February 2004.|
|Licensing Opportunities||We are currently seeking licensing opportunities in all fields for the development of this technology.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2008