Mary Ellen Conley, MD

Member, St. Jude Faculty
UT Joint Appointment

Departments

Immunology


Education

MD - University of California, San Diego

Research Interests

Selected Publications

Conley ME, Farmer DM, Dobbs AK, Howard V, Aiba Y, Shurtleff SA, Kurosaki T. A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease. Clin Exp Immunol (in press 2008).

Van Zelm MC, Geertsema C, Nieuwenhuis N, de Ridder D, Conley ME, Schiff C, Tezcan I, Bernatowska E, Hartwig NG, Sanders EAM, Litzman J, Kondratenko I, van Dongen JJM, van der Burg M. Gross deletions involving IGHM, BTK or Artemis: A model for genomic lesions mediated by transposable elements. Am J Hu Genet 82:320-332, 2008.

Dobbs AK, Yang T, Farmer D, Kager L, Parolini O, Conley ME. A hypomorphic mutation in Igβ in a patient with a leaky defect in B cell development. J Immunol 179:2055-2059, 2007.

Conley ME. Immunodeficiency: UNC-93B gets a toll call. Trends in Immunol 28:99-101, 2007.

Dobbs AK, Yang T, Farmer, DM, Howard V, Conley ME. A possible bichromatid mutation in a male gamete giving rise to a female mosaic for two different mutations in the X-linked gene WAS. Clin Genet 71:171-176, 2007.

Weeks JK, Helton KJ, Conley ME, Onciu M, Khan, RB. Diffuse CNS vasculopathy with chronic Epstein-Barr virus infection in X-linked lymphoproliferative disease. Am J Neuroradiol 27: 884-886, 2006.

Winkelstein JA, Marino MC, Lederman HM, Jones SM, Sullivan K, Burks AW, Conley ME, Cunningham-Rundles C, Ochs HD. X-linked agammaglobulinemia: report on a United States registry of 201 patients. Medicine 85:193-202, 2006.

Crow YJ, Goodship JA, Coady AM, Conley ME, Gennery AR. A newly recognized, likley autosomal recessive syndrome comprising agammaglobulinemia, microcephaly, craniosynostosis, severe dermatitis and other features. Am J Med Genet 140A:1131-1135, 2006.

Broides A, Ault BH, Arthus MF, Bichet DG, Conley ME. Severe combined immunodeficiency associated with nephrogenic diabetes insipidus and a deletion in the Xq28 region. Clin Imm 120:147-155, 2006.

Howard V, Greene JM, Pahwa S, Winkelstein JA, Boyle JM, Kocak M, Conley ME. The health status and quality of life of adults with X-linked agammaglobulinemia. Clin Immunol 118:201-208, 2006.

Broides A, Yang W, Conley ME. Genotype/phenotype correlations in X-linked agammaglobulinemia. Clin Immunol 118:195-200, 2006.

Notarangelo L, Casanova JL, Conley ME, Chapel H, Fischer A, Puck J, Roifman C, Seger R, Geha RS.  Primary immunodeficiency diseases: An update from the International Union of Immunological Societies primary immunodeficiency diseases classification committee meeting in Budapest 2005. J All Clin Immunol 117: 883-896, 2006.

Filipovitch A, Conley ME, Nichols KE, Sullivan KE. X-linked lymphoproliferative syndrome: An X-cellent question. Clin Immunol 119 :241-244, 2006.

Broides A, Ault BH, Arthus MF, Bichet DG, Conley ME. Severe combined immunodeficiency associated with nephrogenic diabetes insipidus and a deletion in the Xq28 region. Clin Imm 120:147-155, 2006.

Crow YJ, Goodship JA, Coady AM, Conley ME, Gennery AR. A newly recognized, likely autosomal recessive syndrome comprising agammaglobulinemia, microcephaly, craniosynostosis, severe dermatitis and other features. Am J Med Genet 140A:1131-1135, 2006.

Winkelstein JA, Marino MC, Lederman HM, Jones SM, Sullivan K, Burks AW, Conley ME, Cunningham-Rundles C, Ochs HD.  X-linked agammaglobulinemia: Report on a United States registry of 201 patients. Medicine 85:193-202, 2006.

Weeks JK, Helton KJ, Conley ME, Onciu M, Khan, RB. Diffuse CNS vasculopathy with chronic Epstein-Barr virus infection in X-linked lymphoproliferative disease. Am J Neuroradiol 27: 884-886, 2006.

Howard V, Greene JM, Pahwa S, Winkelstein JA, Boyle JM, Kocak M, Conley ME. The health status and Quality of life of adults with X-linked agammaglobulinemia. Clin Imm 118:201-208, 2006.

Broides A, Yang W, Conley ME. Genotype/phenotype correlations in X-linked agammaglobulinemia. Clin Imm 118:195-200, 2006.

Conley ME, Partain JD, Norland SM, Shurtleff SA, Kazazian HH Jr. Two independent retrotransposon insertions at the same site within the coding region of Btk. Human Mutation 25:324-325, 2005.

El Saleeby CM, Suzich J, Conley ME, Devincenzo JP. Quantitative effects of Palivizumab and donor-derived T cels on chronic respiratory syncytial virus infection, lung disease, and fusion glycoprotein amino acid sequences in a patient before and after bone marrow transplantation. Cin Infect Dis 39:e17-20, 2004.

Weller S, Braun MC, Tan BK, Rosenwald A, Cordier C, Conley ME, Plebani A, Kumararatne DS, Bonnet D, Tournihac O, Tchernia G, Steiniger B, Staudt LM, Casanova JL, Reynaud CA, Weill JC. Human blood IgM “memory” B cells are circulating splenic marginal zone B cells harboring a pre-diversified immunoglobulin repertoire. Blood 104:3647-3654, 2004.

Hernandez-Trujillo VP, Nguyen WT, Belleau JT, Jeng M, Conley ME, Lew DB. Cow’s mild allergy in a patient with hyper-IgE syndrome. Ann Allergy Asthma Immunol 92:469-474, 2004.

Conley ME, Saragoussi D, Notarangelo L, Etzioni A, Casanova JL. An international study examining therapeutic options used in the treatment of Wiskott-Aldrich syndrome. Clin Immunol 109:272-277, 2003.

Winkelstein JA, Marino MC, Ochs H, Fuleihan R, Scholl PR, Geha R, Stiehm ER, Conley ME. The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients. Medicine 82:373:384, 2003.

Howard V, Myers LA, Williams DA, Wheler G, Turner EV, Cunningham JM, Conley ME. Stem cell transplants for patients with X-linked agammaglobulinemia. Clin Immunol 107:98-102, 2003.

Porpiglia AS, Rohrer J, Conley ME. Reconstitution of B cell function in murine models of immunodeficiency. Clin Immunol 107:90-97, 2003.

Lopez Granados E, Porpiglia AS, Hogan MB, Matamoros N, Krasovec S, Pignata C, Smith CIE, Hammarstrom L, Bjorklander J, Belohradsky BH, Fontan Casariego C, Garcia Rodriguez MC, Conley ME. Clinical and molecular analysis of patients with defect in μ heavy chain gene. J Clin Invest 110:1029-1035, 2002.

Pan Q, Matamoros N, Bjorkander J, Conley ME, Hammarstrom L. Lack of IgA in Cμ deficient patients. Nature Immunol 3:595, 2002.

Conley ME, Howard V. Clinical findings leading to the diagnosis of X-linked agammaglobulinemia. J Pediatr 141:566-571, 2002.

Rapalus L, Minegishi Y, Lavoie A, Cunningham-Rundles C, Conley ME. Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency. Clin Immunol 101:270-275, 2001.

Wang D, Boylin EC, Minegishi Y, Wen R, Smith CIE, Ihle JN, Conley ME. Variations in the human phospholipase Cγ2 gene in patients with B cell defects of unknown etiology. Immunogenetics 53:550-556, 2001.

Minegishi Y, Conley ME. Negative selection at the pre-BCR checkpoint elicited by human μ heavy chains with unusual CDR3 regions. Immunity 14:631-641, 2001.

Doffinger R, Smahi A, Bessia C, Geissmann F, Feinberg J, Durandy A, Bodemer C, Kenwrick S. Dupuis-Girod S, Blanche S, Weeo, P, Rabia SH, Headon DJ, Overbeek PA, Le Deist F, Holland SM, Belani K, Kumararatne DS, Fischer A, Shapiro R, Conley ME, Reimund E, Kalhoff H, Abinun M, Munnich A, Isreal A, Courtois G, Casanova JL. X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Nat Genet 27:277-285, 2001.

Srivannaboon K, Conley ME, Coustan-Smith E, Wang WC. Hypogammaglobulinemia and reduced numbers of B cells in children with myelodysplastic syndrome. Pediatr Hem Onc 23:122-125, 2001.

Villa A, Sobacchi C, Notaragelo LD, Abinun M, Abrahamsen TG, Arkwright PD, Baniyash M, Brooks EG, Bozzi F, Conley ME, Cortes P, Duse M, Fasth A, Filipovich AM, Friedrich W, Infante AJ, Jones A, Pasic S, Rechavi G, Mazzolari E, Santagata S, Schroeder ML, Seger R, Strina D, Ugazio A, Väliaho J, Vihinen M, Ochs H, Vezzoni P, Schwarz K. V(D)J recombination defects in lymphocytes due to Rag mutations: a severe immunodeficiency with a spectrum of clinical presentations. Blood 97:81-88, 2001.

Richter D, Conley ME, Rohrer J, Myers LA, Zahradka K, Keleèiae J, Sertiae J, Stavlgeniae-Rukavina A. A contiguous deletion syndrome of X-linked agammaglobulinemia and sensorineural deafness. Pediatr All Immunol 12:107-111, 2001.

Webb CF, Yamashita Y, Ayers N, Evetts S, Paulin Y, Conley ME, Smith EA. The transcription factor Bright associates with Btk, the defective protein in xid. J Immunol 165:6956-6965, 2000.

Minegishi Y, Lavoie A, Cunningham Rundles C, Bedard PM, Hebert J, Cote L, Dan K, Sedlak D, Buckley RH, Fischer A, Durandy A, Conley ME. Mutations in activation induced cytidine deaminase in patients with Hyper IgM Syndrome. Clin Immunol 97:203-210, 2000.

Slobod KS, Sandlund JT, Spiegel PH, Haik B, Hurwitz JL, Conley ME, Bowman LC, Benaim E, Jenkins JJ, stocks RMS, Gan YJ, Sixbey JW. Molecular evidence of ocular Epstein-Barr Virus infection. Clin Infect Dis 31: 184-188, 2000.

 

Last update: September 2011