RERTEP: A Phase II Trial of Surgery and fractionated Re-Irradiation for Recurrent Ependymoma


Radiology : recurrent ependymoma


Ependymoma is an aggressive brain tumor. St. Jude investigators have shown that when it grows back after being treated for the first time with surgery, radiation or even chemotherapy, a combination of additional surgery and radiation may be used successfully in certain patients. The goal of this study is to confirm the ability of a second course of surgery and radiation therapy to control recurrent ependymoma and identify which patients are most likely to benefit from this type of treatment. The study will also evaluate the effects of the tumor and treatment with the hope of reducing long-term side effects. Recurrence of ependymoma after initial treatment may be local, distant, or both. Local recurrence means that the tumor has regrown where it was originally located in the brain. Distant recurrence means that the tumor has regrown at a site in the brain or spine other than the original location. How additional surgery and radiation therapy are used in this study depends on whether the recurrence was local, distant or both.


Primary Objective:

To estimate the progression-free and overall survival distributions for children and young adults with recurrent Ependymoma treated with a second course of irradiation while monitoring for excessive central nervous system necrosis.

Secondary Objective:

Evaluate functional outcomes and host and tumor biology in patients with recurrent Ependymoma treated with a second course of irradiation.

Eligibility criteria, among others, include:

For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).


Thomas E. Merchant, DO, PhD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
FAX: 901-595-4011

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