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St. Jude investigators have discovered how a single molecular "on switch" triggers gene activity that might cause effects ranging from learning and memory capabilities to glucose production in the liver.
A biochemical mechanism that cells use to cope with hypoxia (lack of oxygen) actually cooperates with a less well-known mechanism that helps increase the expression of those hypoxia-sensitive genes.
Novel compounds that prevent a protein called TORC2 from moving from the cytoplasm and into the nuclei of liver cells might be able to reduce high blood sugar in people with diabetes.
Inactivation of the gene CBP in certain immature white blood cells of mice causes lymphoma, a type of cancer also found in humans. The cancer is accompanied by changes in the expression of specific genes associated with development of the disease.