Novel Antibiotics and Methods of Use (SJ-97-0033)

Technology Name
(St. Jude Reference #)
Novel Antibiotics and Methods of Use (SJ-97-0033) 
Description A peptide produced by the bacteria has been identified, which is capable of killing bacterial cells that have developed resistance to multiple antibiotics, such as penicillin and vancomycin. This peptide was shown to be effective in conjunction with penicillin in killing bacteria cells that have become tolerant of many antibiotics.
Keywords  Peptide, antibiotic resistant, antibiotic tolerant, His-Asp pathway
Granted Patents or Published Applications US patent Nos. 6,630,583; 6,448,224; 6,331,407
Related Scientific References

Novak, R., et al., "Emergence of vancomycin tolerance in Streptococcus pneumoniae" Nature 160;399: 590-593 (1999);

Novak, R., et al., "NoveI identification of a Streptococcus pneumoniae gene locus encoding proteins of an ABC phosphate transporter and a two-component regulatory system" J Bacteriol. 181(4): 1126-33 (1999).

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Last update: April 2014