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Research
| Technology Name (St. Jude Reference #) | Novel Antibiotics and Methods of Use (SJ-97-0033) |
| Description | A peptide produced by the bacteria has been identified, which is capable of killing bacterial cells that have developed resistance to multiple antibiotics, such as penicillin and vancomycin. This peptide was shown to be effective in conjunction with penicillin in killing bacteria cells that have become tolerant of many antibiotics. |
| Keywords | Peptide, antibiotic resistant, antibiotic tolerant, His-Asp pathway |
| Granted Patents or Published Applications | US patent Nos. 6,630,583; 6,448,224 |
| Related Scientific References | Novak, R., et al., "Emergence of vancomycin tolerance in Streptococcus pneumoniae" Nature 160;399: 590-593 (1999); Novak, R., et al., "NoveI identification of a Streptococcus pneumoniae gene locus encoding proteins of an ABC phosphate transporter and a two-component regulatory system" J Bacteriol. 181(4): 1126-33 (1999). |
| Licensing Opportunities | We are currently seeking licensing opportunities in all fields for the development of this technology. |
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2010
