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    Yang: News Releases & Feature Stories

    Researchers map "genomic landscape" of childhood adrenocortical tumors for the first time

    St. Jude Children’s Research Hospital scientists identify key molecular events in pediatric adrenocortical tumors; findings could help clinicians identify most malignant subtypes and lead to better treatment. (Raul Ribeiro, MD; Jinghui Zhang, PhD; and Gerard Zambetti, PhD)

    Digging deeper to save lives and hearing

    Cisplatin is one of the most widely used anti-cancer drugs. Many patients treated with the drug also have serious side effects like hearing loss.

    Inherited gene variations tied to treatment-related hearing loss in cancer patients

    St. Jude Children’s Research Hospital scientists have identified inherited genetic variations associated with hearing loss in young cancer patients treated with cisplatin, a drug widely used to treat adults with cancer. (Jun J. Yang, PhD, Clinton Stewart, PhD, and Giles Robinson, MD)

    Drug side effects explained in patients of East Asian ancestry

    St. Jude scientists have linked inherited variations in a second gene to reduced tolerance of a key cancer drug. Findings will aid efforts to improve chemotherapy safety and effectiveness.

    Inherited gene variation helps explain drug toxicity in patients of East Asian ancestry

    St. Jude researchers have identified an inherited variation in the NUDT15 gene that is strongly associated with a low tolerance for a drug that is a mainstay of pediatric ALL treatment. The finding is expected to impact ALL treatment. (Jun J. Yang, PhD)

    Inherited gene variation tied to high-risk pediatric leukemia and greater risk of relapse

    Study led by St. Jude Children’s Research Hospital finds an inherited gene variation—more common among Hispanic Americans–is tied to increased risk of developing a high-risk form of pediatric leukemia. (Dr. Jun Yang)

    Risky Business

    Scientists have long known that Hispanic children are at higher risk of developing ALL than white or African-American kids.

    Inherited genetic variations have a major impact on childhood leukemia risk

    Study links inherited genetic variations in a few genes to increased risk of acute lymphoblastic leukemia (ALL) and helps to explain ethnic differences in the cancer’s incidence. (Dr. Jun J. Yang)

    Inherited risk factors for childhood leukemia are more common in Hispanic patients

    Results from a St. Jude Children’s Research Hospital and the Children’s Oncology Group study pinpoint genetic basis for increased leukemia risk facing Hispanic children and provide new hope for closing survival gap. (Dr. Jun Yang)

    Native American ancestry linked to greater risk of relapse in young leukemia patients

    New research from St. Jude Children’s Research Hospital and the Children’s Oncology Group ties the genetic variation characteristic of Native American ancestry to higher odds cancer will return and highlights a strategy to ease the racial disparities in survival.