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(St. Jude Reference #)
|Diagnostic for Influenza Virulence (SJ-11-0029)|
|Description||Our researchers have identified 4 amino acid residues within the influenza A virus PB1-F2 protein that are excellent predictors of the virulence of the associated virus strain. This discovery can be used to develop a simple diagnostic test to detect virulent influenza strains within a virus sample.|
|Keywords||Influenza, virulence, PB1-F2|
|Granted Patents or Published Applications||U.S. application pending|
|Related Scientific References||Alvmova, I.V. et al.,”Mapping the Functional Domains of the Infuenza A Virus PB1-F2 Protein”, poster presentation at the Negative Strand Virology Meeting, Brussels, Belgium (June 22, 2010);
McAuley, J.L. et al., “PB1-F2 Proteins from H5N1 and 20th Century Pandemic Influenza Viruses Cause Immunopathology”, PLOS Pathogens 6(7): e1001014 (epub. July 2010);
Smith, A.M. et al., “Effect of 1918 PB1-F2 Expression on Influenza A Virus Infection Kinetics”, PLOS Computational Biology 7(2): e1001081 (epub. Feb. 2011)
|Licensing Opportunities||We are currently seeking licensing opportunities for the development of a diagnostic test based on this technology|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: March 2012