Clayton Naeve, PhD

Clayton W. Naeve, PhD

Member, St. Jude Faculty
Senior Vice President & Chief Information Officer
Endowed Chair in Bioinformatics
Director, Hartwell Center for Bioinformatics and Biotechnology

Departments

Administration
Information Sciences

Divisions

Hartwell Center

Contact Information

Clayton Naeve, PhD
Information Sciences/Administration
MS 278, Room D-1007D
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: clayton.naeve@stjude.org
Phone: (901) 595-4449
FAX: (901) 595-2945

Education

PhD - Colorado State University

Research Interests

  • Bioinformatics
  • High-throughput biotechnologies

 

Selected Publications

Chen X, Hale GA, Neale GA, Knowles J, Barfield RC, Wang YD; Kaushal D, Naeve DC, Srivastava DK, Tong X, Turner V, Naeve CW, Handgretinger R. A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation. Exp Hematol 35:831-841, 2007.

Krauss S, Obert CA, Franks J, Walker D, Jones K, Seiler P, Niles l, Pryor SP, Obenauer JC, Naeve CW, Widjaja L, Webby RJ, Webster RG. Influenza in Migratory Birds and Evidence of Limited Intercontinental Virus Exchange. PloS Pathology 3: 1-10, 2007.

Finkelstein DB, Mukatira S, Mehta PK, Obenauer JC, Su X, Webster RG, Naeve CW. Persistent Host Markers in Pandemic and H5N1 Influenza Viruses. J Virol 81: 10292-10299, 2007.

Obenauer JC, Denson J, Mehta PK, Su X, Mukatira S, Finkelstein DB, Xu X, Wang J, Ma J, Fan Y, Rakestraw KM, Webster RG, Hoffmann E, Krauss S, Zheng J, Zhang Z, Naeve CW. Large Scale Sequence Analysis of Avian Influenza Isolates. Science 311:1576-1580, 2006.

Cheok MH, Yang W, Pui C, Downing JR, Cheng C, Naeve CW, Relling MV, Evans WE. Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nature Genetics  85-90, 2003.

Kuefer MU, Chinwalla V, Zeleznik-Le NJ, Behm FG, Naeve CW, Rakestraw KM, Raimondi C, Morris, SW. Characterization of the MLL Partner Gene, AF15q14, involved in the t(11;15)(1q23;q14-15). Oncogene 22:1418-1424, 2003.

Yeoh E-J, Ross ME, Shurtleff SA, Williams KW, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui C-H, Evans WE, Naeve C, Wong L, Downing, JR. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell (1-2):133-143, 2002.

Patel DH, Crawford CR, Naeve CW, Belt JA. Cloning, genomic organization and chromosoma localization of the gene encoding the murine sodium-dependent, purine-selective, concentrative nucleoside transporter (CNT2). Gene 242(1-2):51-58, 2000.

Buck GA, Fox JW, Gunthorpe M, Hager KM, Naeve CW, Pon RT, Adams PS and Rush J. Design strategies and performance of custom DNA sequencing primers. Biotechniques 27:528-36, 1999.

Harada H, Harada Y, O’Brien DP, Rice DS, Naeve CW, Downing JR. HERF1, a novel hematopoietic specific RING-finger protein is required for terminal differentiation of erythroid cells. Mol Cell Biol 19:3808-15, 1999.

Bodner SM, Naeve CW, Rakestraw RM, Jones BG, Valentine VA, Valentine MB, Luthardt FW, Willman CL, Raimondi SC, Behm FG, Downing JR, Roussel MF, Sherr CJ and Look AT. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). Gene 229:223-8, 1999.

Hitzler JK, Witte D, Jenkins N, Naeve CW, Look AT and Morris SW.  cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in MDS and AML. Am J Path 155:53-9, 1999.

Danks MK, Morton CL, Krull EJ, Cheshire PJ, Richmond LB, Naeve CW, Pawlik CA, Houghton PJ, Potter PM. Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy. Clin Cancer Res 5:917-924, 1999.

Zhang W, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, Rakestraw RM, Naeve CW, Beckmann G, Weisenburger DD, Sanger WG, Nowotny H, Vesely M, Callet-Bauchu E, Salles G, Dixit VM, Rosenthal A, Schlegelberger B, and Morris SW. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nature Genetics 22:1-6, 1999.

Kurosawa H, Inukai T, Inaba T, Goi K, Chang K-S, Sinjyo T, Rakestraw KM, Naeve CW and Look AT. Two Candidate Downstream Target Genes for E2A-HLF. Blood 93:321-332, 1999.

Potter PM, Pawlik CA, Morton CL, Naeve CW, and Danks MK.  Isolation and Partial Characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug Irinotecan (CPT-11). Cancer Res 58:2646-2651, 1998.

Crawford CR, Patel DH, Naeve C and Belt JA. Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. J Biochem 273:5288-5293, 1998.

Ivanetich KM, Bibbs L, Niece RL, Denslow ND, Naeve CW and Ericsson LH. Biotechnology facility instrumentation survey. Genetic Engineering News August, pp. 17, 47, 49, 1997.

Morris S, Naeve C, Mathew P, James PL, Kirstein MN, Cui X and Witte DP. ALK, The chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin’s lymphoma, encodes a novel neural-specific receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 14:2175-2188, 1997.

Wilkinson DA, Neale GAM, Mao S, Naeve CW and Goorha RM. Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia. Leukemia 11:86-96, 1997.

Pon RT, Buck GA, Hager KM, Naeve CW, Niece RL, Robertson M and Smith AJ.  A multi-facility survey of oligonucleotide synthesis and an examination of the performance of unpurified primers in automated DNA sequencing. BioTechniques 21:680-685, 1996.

Kuefer MU, Look AT, Williams DC, Valentine V, Naeve CW, Behm FG, Mullersman JE, Yoneda-Kato N and Morris SW. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). Genomics 35:392-396, 1996.

 

Last update: July 2009

 

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