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Leukemias / Lymphomas : High risk Hodgkin lymphoma
Hodgkin lymphoma is a cancer of the lymph system (a part of the body’s immune system). The lymph system is made up of tissue throughout the body that makes and stores infection-fighting cells. The term “risk” refers to the chance of the cancer coming back after treatment.
In this study, a commonly used multi-drug chemotherapy (anti-cancer) regimen for Hodgkin lymphoma will be used called “OEPA/COPDac”, except that a new drug called “brentuximab vedotin (also called Adcetris®)” will be substituted for one of the usual drugs called vincristine, making this treatment “AEPA/CAPDac”. Brentuximab vedotin is a drug known as an “antibody-drug conjugate (ADC)”. It is made up of 2 parts. The first part is a type of antibody (a man-made version of an immune system protein) that finds and attaches to the surface of most lymphoma cells. The second part is a chemotherapy (anti-cancer) drug that stops the cancer cell from dividing, and kills the cancer cell.
This study has 2 parts:
1. Treatment phase: treatment with chemotherapy and in some participants, radiation therapy. Radiation will start within 2-3 weeks after completing all CAPDac chemotherapy and blood counts have recovered. Radiation treatments will be given to lymph node groups that did not go into remission after the first 2 cycles of AEPA chemotherapy.
2. Follow-up phase: monitor you long-term to look for signs Hodgkin lymphoma has returned and for late effects of treatment
For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).
Monika Metzger, MD, MS
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
Referring or consulting physicians only: firstname.lastname@example.org
For all other inquiries about St. Jude Children's Research Hospital studies: email@example.com
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.