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Hematologic Disorders : Sickle cell anemia
Transcranial Doppler is a medical test that uses sound waves to measure blood flow through the major blood vessels of the brain. The test is most useful at detecting decreased blood flow through narrow areas inside blood vessels; Transcranial Doppler (TCD) is especially useful for monitoring blood flow in the brain of stroke patients who are affected by brain swelling and vasospasm (which are cerebral blood vessel spasms). Abnormal (very high) TCD results are a serious problem for children with sickle cell anemia.Having conditional TCD values means the patient is at greater risk for converting (changing) to an abnormal TCD, and then having an increased risk for stroke.
This study focuses on children who have sickle cell anemia and a recent “conditional” TCD exam; half of the children in this study with conditional TCD exams will receive their normal treatment for sickle cell disease and half will receive the research treatment, hydroxyurea. Hydroxyurea is used to prevent pain episodes and is approved in the United States by the United States Food and Drug Administration (FDA) for adults with sickle cell anemia. Because hydroxyurea is not yet approved for children with sickle cell anemia with conditional TCD, this study is considered research.
For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).
Jane Hankins MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-866-2ST-JUDE (1-866-278-5833)
Referring or consulting physicians only: firstname.lastname@example.org
For all other inquiries about St. Jude Children's Research Hospital studies: email@example.com
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.