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Sharon Frase

Sharon Frase

Director of Electron Microscopy

Contact Information

Sharon Frase
Cell and Tissue Imaging Center
MS 312, Room DP003
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone:  (901) 595-6499
Email: sharon.frase@stjude.org


Research Interests

Mrs. Frase received her initial training in histology and electron microscopy at St. Jude Children’s Research Hospital and during her 35 year career has established shared resource facilities at the University of Tennessee Health Science Center and the University of Memphis. Her laboratory focus is on establishing standard procedures for immunogold techniques and TEM tomography analysis. She is also interested in developing partnerships with other institutions to allow St Jude researchers access to new technology.


Education

Memphis State University, Memphis, TN
Certified Electron Microscopy Technologist, Microscopy Society of America
ASCP Registered Histologist


Selected Publications

Judge D, Payant J , Frase S, Wood TO  Anterior stromal micropuncture electron microscopic changes in the rabbit cornea. Cornea Apr: 9(2): 152-160, 1990.

Fitzgerald MEC, Frase S, Hodos W, and Reiner A.  Outer retinal and choroidal pathology in aged pigeons. Invest Ophthalmol Vis Sci (Suppl.) 35(4), 1952, 1994.

Fitzgerald MEC, Frase S, Miller RF, Hodos W, Reiner A.  Decrease in the abundance of choroidal vessels is correlated with loss of visual acuity in aged pigeons.  Invest Ophthalmol Vis Sci (Suppl) 35(4), S553, 1995.

Lamoreaux WJ, Fitzgerald MEC, Needham, GR, Frase S, Bayakly N, and Coons LB.  Localization of nitric oxide synthase in the salivary gland dusts of feeding female dermacentor variabilis (Say) and the effect of endogenous nitric oxide on isolated salivary gland ducts.  Microscopy & Microanalysis (Midroscopy Society of America ) Cleveland, OH, 1997.

Fitzgerald MEC, Tolley E, Frase S, Zagvazdin, Y, Miller RF, Hodos W, Reiner A.  Functional and morphological assessment of age-related changes in the choroidal and outer retina in pigeons.  Vis Neurosci 18:1-19, 2001.

Song L, Ying Y, Xiangying C, Mitchell S, Shuangying L, Songmai M, Gallagher JW, Shelness GS, Mahan J, Frase S, Mansbach CM, Weinberg RB, Black DD.  Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size. Dec. 2005. eprint

Johnson DA, Zhang J, Frase S, Wilson M, Rodriguez-galindo C, dyer MA.  Neuronal Differentiation and synaptogenesis in retinoblastoma.  Cancer res 2007 Mar 15;67 (6):2701-11. 

Ajioka I, Martins RA, Bayazitov IT, Donovan S, Johnson DA, Frase S, Cicero SA, Boyd K, Zakharenko SS, Dyer MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell 2007 Oct 19;131 (2):378-901.