Direct Haplotyping Method (SJ-01-0003)

Technology Name
(St. Jude Reference #)
Direct Haplotyping Method (SJ-01-0003)
Description A simple method for determining the haplotype structure of nucleotide polymorphisms that occur over several kilobases is provided.  The method utilizes conventional and long range PCR in genomic DNA and intramolecular ligation techniques.
Keywords Haplotype, haplotyping, PCR, nucleotide polymorphisms
Granted Patents or Published Applications U.S. Patent No. 7,041,447 granted May 9, 2006
Related Scientific References McDonald, O.G. et al.,”Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation”, Pharmacogenetics 12(2): 93-99 (2002); see also associated commentary by Markus Nothen and Sven Cichon in this same journal issue at pages 89-90. 
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Last update: June 2006