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Finding Cures. Saving Children.
Immunology
Immunology is the study of the immune system, the body¹s defense against infectious disease. In this complex system a defect in a single gene or the control of a single cell can have an enormous effect on the health of the individual. In this way, the immune system and cancer are similar. The Department of Immunology at St. Jude studies the biology of the system whose cells are a major source of childhood cancers, and by understanding these cells and how they are controlled, we gain new insights into such cancers.
The department is highly interactive, both internally and with other groups at St. Jude, and such interactions are essential for progress in modern biomedical science. The various laboratories utilize contemporary biochemical, molecular and cellular approaches to analyze aspects of the function of the immune system, and much of the research depends on the Hartwell Center for reagents and expertise, and the Animal Resources Center for their remarkable services. The evolving gene array and proteomics facilities in the Hartwell Center are increasingly utilized in our research.
All investigators make extensive use of the sophisticated departmental facilities for flow cytometry, microscopy, and the production of immunologic molecules. Weekly seminar and journal club programs facilitate discussion within the department. Faculty members, postdoctoral fellows and graduate students present in both these formats at least once a year.
The spectrum of research includes the identifying the genetic defects in pediatric immunodeficiency disease, basic studies of lymphocyte activation and function, the innate immune response and how it impacts on adaptive immunity, the host response to viruses, the cellular response to stress, and the signaling pathways controlling cell death and survival. All members of the department benefit greatly from the free and open research environment at St. Jude.
Douglas R. Green, PhD, is the chair of St. Jude's Immunology Department.
