Non-Therapeutic Protocol
BRAIN2: The Brigance Assessment Of Individual Neurodevelopment In Young Children With Sickle Cell Disease-2
Type of Protocol/Clinical Study
Associated Hematology Studies : Sickle cell disease
Description
Central nervous system complications including stroke, silent infarcts (death of tissue due to a lack of blood flow) and neurocognitive difficulties (difficulty with thinking and learning) are some of the most overwhelming consequences of sickle cell disease (SCD). As a result, young children with SCD may have academic problems. Most studies involving neurocognitive testing of children with SCD have focused on school-aged children; very few have examined preschool-age children. Because thinking and learning difficulties appear to begin before a child with SCD is 5 years old, this study will focus on 3-year olds. The participants will be given the Brigance Preschool Screen-II, one of the most often used tests to study learning development. The duration of the study will be for 3 years.
Objectives
- The primary goal of the BRAIN2 study is to administer Brigance Preschool Screen – II to 3 year old children with and without SCD who come from similar socioeconomic backgrounds and compare the results between the two groups.
- To compare the raw scores of the Brigance Preschool Screen- II between SCD and control groups.
Eligibility
Inclusion Criteria
- Patients should be between three and less than 4 years of age
- African-American
- In addition, children in the sickle cell group will have a confirmed diagnosis of SCD. Children in the comparison group will have no known diagnosis of SCD.
Exclusion Criteria
- Down syndrome, a known developmental problem, or have had a stroke
- Previously tested with Brigance Preschool Screen-2
Principal Investigator
Winfred Wang, MD
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