Terrence Geiger, MD, PhD

    Terrence L. Geiger, MD, PhD

    Member, St. Jude Faculty
    Medical Director, Clinical Pathology
    Interim International Outreach Program Co-Director

    Departments

    Pathology

    Contact Information

    Terrence Geiger, MD, PhD
    Pathology
    MS342, Room D4047E
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: terrence.geiger@stjude.org

    Education

    MD - Yale University (1993)
    PhD - Yale University (1993)


    Research Interests


    Clinical Interests


    Selected Publications

    Alli R, Nguyen P, Boyd K, Sundberg JP, Geiger TL. A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. J Immunol 188(1):477-86, 2012.

    Alli R, Nguyen P, Geiger TL. Altered differentiation, diminished pathogenicity, and regulatory activity of myelin-specific T cells expressing an enhanced affinity TCR. J Immunol 187(11):5521-31, 2011.

    Nguyen P, Ma J, Pei D, Obert C, Cheng C, Geiger TL. Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire. BMC Genomics 12(106):1-13, 2011.

    Alli R, Zhang ZM, Nguyen P, Zheng JJ, Geiger TL. Rational design of T cell receptors with enhanced sensitivity for antigen. PLoS One 6(3):18027, 2011.

    Udyavar A, Geiger TL. Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy. Arch Immunol Ther Exp (Warsz) 58(5):335-346, 2010.

    Nguyen P, Liu W, Ma J, Manirarora JN, Liu X, Cheng C, Geiger TL. Discrete TCR repertoires and CDR3 features distinguish effector and Foxp3(+) regulatory T lymphocytes in myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis. J Immunol 185(7):3895-904, 2010.

    Nguyen P, Geiger TL. Induction of B cell immune tolerance by antigen-modified cytotoxic T lymphocytes. Transplantation 89: 667-676, 2010.

    Liu X, Nguyen P, Liu W, Cheng C, Steeves M, Obenauer JC, Ma J, Geiger TL. T cell receptor CDR3 sequence but not autoantigen recognition characteristics distinguish autoreactive effector and Foxp3+ regulatory T cells. Immunity 31: 909-920, 2009. 

    Udyavar A, Alli R, Nguyen P, Baker L, Geiger TL. Subtle affinity enhancing mutations in a MOG-specific TCR revise specificity and generate new self-reactivity. J Immunol 182: 4439-4447, 2009.

    Alli R, Nguyen P, Geiger TL. Retrogenic modeling of experimental allergic encephalomyelitis associates T-cell frequency but not T-cell receptor functional affinity with pathogenicity. J Immunol 181: 136-145, 2008.

    Inaba H, Fan Y, Pounds S, Geiger TL, Rubnitz JE, Ribeiro RC, Pui CH, Razzouk B. Clinical and biological features and treatment outcome of children with newly diagnosed acute myeloid leukemia and hyperleukocytosis. Cancer 113: 522-529, 2008.

    Inaba H, Steeves M, Nguyen P, Geiger TL. In vivo suppression of naïve CD4 T-cell responses by IL-2 and antigen stimulated T-lymphocytes in the absence of APC competition. J Immunol 181: 3323-3335, 2008.

    Selvaraj R, Geiger TL. Mitigation of experimental allergic encephalomyelitis by TGF-β induced, Foxp3+ regulatory T-lymphocytes through the induction of anergy and infectious tolerance. J Immunol 180: 2830-2838, 2008.

    Moisini I, Nguyen P, Fugger L, Geiger TL.  A humanized myelin basic protein-HLA-DR2-CD28-ζ chimeric receptor re-directs therapeutic T-cells against myelin-specific T-lymphocytes and blocks EAE. J Immunol 180: 3601-3611, 2008.

    Nguyen P, Duthoit CT, Geiger TL.  Induction of tolerance and immunity by re-directed B-cell-specific cytolytic T-lymphocytes.  Gene Therapy 14: 1739-49, 2007.

    Chaleff S, Otto M, Barfield RC, Leimig T, Iyengar R, Martin J, Holiday M, Houston J, Geiger T, Huppert V, Handgretinger R.  A large scale method for the selective depletion of αβ T-lymphocytes from PBSC for allogeneic transplantation. Cytotherapy 9: 746-754, 2007.

    Selvaraj R, Geiger TL. A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-β. J Immunol 178: 7667-7677, 2007. (re-published 179: 1390-1401, 2007 due to publisher errors).

    Peng J, Dicker B, Du W, Tang F, Nguyen P, Geiger T, Wong S, Wen L. Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction. J Autoimmunity 28: 188-200, 2007.

    Sanders RP, Geiger TL, Heddle N, Pui CH, Howard SC.  A Revised Classification Scheme for Acute Transfusion Reactions. Transfusion 46: 621-628, 2007.

    Wang Y, Liu Y, Wu C, Zhang H, Zheng X, Zheng Z, Geiger TL, Nuovo GJ, Liu Y, Zheng P. Epm2a suppresses tumor growth in the immune compromised host by inhibiting Wnt signaling. Cancer Cell 10: 179-190, 2006.

    Inaba H, Geiger TL.  Defective cell cycle induction by IL-2 in naïve T-cells antigen-stimulated in the presence of refractory T-lymphocytes. Intl Immunol 18: 1043-1054, 2006.

    Sanders RP, Maddirala SD, Geiger TL, Pounds S, Sandlund JT, Ribeiro RC, Pui CH, Howard SC. Premedication with acetaminophen or diphenhydramine does not affect the risk of febrile nonhemolytic or allergic transfusion reactions in pediatric hematology, oncology, and stem cell transplantation patients. Br J Haematol 130: 781-787, 2005.

    Mekala DJ, Alli R, Geiger TL. Induction of infectious tolerance and IL-10-secreting regulatory T-cells by redirected CD4+CD25+ T-lymphocytes. Proc Natl Acad Sci USA 102: 11817-11822, 2005.

    Duthoit CT, Mekala DJ, Alli R, Nguyen P, Geiger TL. Uncoupling of IL-2 signaling from cell-cycle progression in naïve CD4+ T-cells by regulatory CD4+CD25+ T-cells. J Immunol 174: 155-163, 2005.

    Mekala DJ, Alli R, Geiger TL. IL-10 dependent treatment of EAE by the antigen-specific re-direction of Th2 T-lymphocytes against MBP-specific autoreactive T-cells. J Immunol 174: 3789-3797, 2005.

    Lowe EJ, Pui CH, Hancock ML, Geiger TL, Khan RB, Sandlund JT. Early Complications in Children with Acute Lymphoblastic Leukemia Presenting with Hyperleukocytosis. Ped Blood and Cancer 44: 1-6, 2005.

    Mekala DJ, Geiger TL. Immunotherapy of autoimmune encephalomyelitis with re-directed CD4+CD25+ T-lymphocytes. Blood 105: 2090-2092, 2005.

    Inaba H, Geiger TL, Lasseter OE, Wang WC. A case of hemoglobin SC disease with cold agglutinin-induced hemolysis. American J Hematol 78: 37-40, 2005.


    Last update: January 2012