A Method for Suppressing Over Reaction of the Immune System in Response to Infection (SJ-09-0006)



Technology Name
(St. Jude Reference #)
Methods for Suppressing a Particular Dendritic Cell Population (tipDC) in Response to Infection (SJ-09-0006)
Description St. Jude investigators found that treatment with a peroxisome proliferator-activated receptor-γ (PPAR γ) agonist reduces the number of a particular dendritic cell population, tipDC, that is increased in response to an infection. They found that moderating, but not eliminating, tipDC recruitment can modulate the host immune response and prevent hypercytokinemia. Treatment with a PPAR γ agonist may be a useful therapeutic intervention in the case of an influenza pandemic outbreak.
Keywords Infection, hypercytokinemia, PPAR γ agonist
Granted Patents or Published Applications US Pub. 2012/022133
Related Scientific References Adridge J, et al. (2009) TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci USA 106:5306–5311.
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Last update: April 2014