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(St. Jude Reference #)
|Methods for Suppressing a Particular Dendritic Cell Population (tipDC) in Response to Infection (SJ-09-0006)|
|Description||St. Jude investigators found that treatment with a peroxisome proliferator-activated receptor-γ (PPAR γ) agonist reduces the number of a particular dendritic cell population, tipDC, that is increased in response to an infection. They found that moderating, but not eliminating, tipDC recruitment can modulate the host immune response and prevent hypercytokinemia. Treatment with a PPAR γ agonist may be a useful therapeutic intervention in the case of an influenza pandemic outbreak.|
|Keywords||Infection, hypercytokinemia, PPAR γ agonist|
|Granted Patents or Published Applications||Pending International PCT Application published July 29, 2010 as WO 2001/085385|
|Related Scientific References||Adridge J, et al. (2009) TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci USA 106:5306–5311.|
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Last update: September 2010