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Finding Cures. Saving Children.
Douglas R. Green, PhD
Member, St. Jude Faculty
Chair, Immunology
Peter C. Doherty Endowed Chair of Immunology
Departments
Immunology
Contact Information
Douglas Green, PhD
Immunology
MS 351, Room E7050
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: douglas.green@stjude.org
Phone: (901) 595-3470
FAX: (901) 595-3107
Education
PhD - Yale University, New Haven, Connecticut (1981)
Research Interests
Central mechanisms of apoptosis in cancer and the immune system
Selected Publications
Green DR, McKinnon PJ. A survivor hits the breaks. Mol Cell 29, 411-412, 2008.
Green DR. Fas Bim Boom! Immunity 28, 141-143, 2008.
Sanjuan MA, Dillon C, Tait SWG, Moshiach S, Dorsey F, Connell S, Komatsu M, Tanaka K, Cleveland JL, Withoff S, Green DR. Toll-like receptor signaling in macrophages links the autophagy pathway to phagocytosis. Nature 450, 1253-1257, 2007.
McStay GP, Salvesen GS, Green DR. Overlapping cleavage motif selectivity of caspases—implications for analysis of apoptotic pathways. Cell Death Diff 15, 322-331, 2007.
Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Barbry P, Newmeyer DD, Beere HM, Green DR. GAPDH and autophagy protect cells from caspase-independent cell death. Cell 129, 983-997, 2007.
Tu S, McStay GP, Boucher LM, Mak T, Beere HM, Green DR. In situ “trapping” of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Nature Cell Biol 8, 72-77, 2006.
Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of Mcl-1. Mol Cell 21, 749-760, 2006.
Muñoz-Pinedo C, Guío-Carrión A, Goldstein JC, Fitzgerald P, Newmeyer DD, Green DR. Different mitochondrial inter-membrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration. Proc Natl Acad Sci USA 103, 11573-11578, 2006.
Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR.Puma couples the nuclear and cytoplasmic pro-apoptotic function of p53. Science 309, 1732-1735, 2005.
Janssen EM, Droin NM, Lemmens EE, Pinkoski MJ, Bensinger SJ, Ehst BD, Griffith TS, Green DR and Schoenberger SP. (shared senior authorship) T help controls CD8+ T cell memory through regulation of TRAIL-mediated AICD. Nature 434, 88-93, 2005.
Chipuk JE, Green DR. Do apoptotic pathways trigger caspase-independent cell death? Nature Rev Mol Cell Biol 6, 268-275, 2005.
Green DR. Apoptotic pathways: ten minutes to dead. Cell 121, 671-674, 2005.
Spierings D, McStay G, Saleh M, Bender C, Chipuk J, Maurer U, Green DR. Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science 310, 66-67, 2005.
Pagliari LJ, Kuwana T, Bonzon C, Tu S, Beere HM, Green DR. The multidomain pro-apoptotic molecules Bax and Bak are directly activated by heat. Proc Natl Acad Sci USA, 102, 17975-17980, 2005.
Last update: March 2008
