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Research
Palazzolo I, Stack C, Kong L, Musaro A, Adachi H, Katsuno M, Sobue G, Taylor JP, Sumner C, Fischbeck KH, Pennuto M. Overexpression of IGF-1 attenuates disease in a mouse model of spinal and bulbar muscular atrophy. Neuron Aug 13;63(3):316-28, 2009.
Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neurons diseases. J Neurosci 29(25):8236-47, 2009.
Salajegheh M, Pinkus JL, Taylor JP, Amato AA, Nazareno R, Baloh RH, Greenberg SA. Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis. Muscle and Nerve 40(1):19-31, 2009.
Salomons FA, Menendez-Benito V, Bottcher C, McCray BA, Taylor JP, Dantuma NP. Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress. Mol Cell Biol 29(7):1774-1785, 2009.
Young J, Garden G, Martinez R, Tanaka F, Sandoval C, Smith A, Sopher B, Lin A, Fischbeck KH, Taylor JP, La Spada AR. Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. J Neurosci 29(7):1987-1997, 2009.
Taylor JP. Diagnosis and treatment of cerebellar ataxia in adults. In: UpToDate, Basow, DS, UpToDate, Waltham, MA, 2009.
Nedelsky NB, Todd PK, Taylor JP. Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochim Biophys Acta 1782(12), 691-699, 2009.
Pandey UB, Nie ZP, Batlevi Y, McCray BA, Ritson GP, Schwartz SL, DiProspero N, Knight M, Schuldiner O, Padmanabhan R, Hild M, Berry D, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the ubiquitin-proteasome system. Nature 447, 859-863, 2007.
Guinto, JB, Ritson GP, Taylor JP, Forman MS. Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy Acta Neuropath 114(1):55-61, 2007.
Neumann M, Mackenzie MD, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS. TDP-43 in ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol 66, 152-7, 2007.
Piccioni F, Romano B, Fischbeck KH, Taylor JP. A screen for drugs that protect against the toxicity of polyglutamine-expanded androgen receptor. Hum Molec Genet 13(4), 437-446, 2004.
Taylor JP, Taye AA, Campbell C, Kazemi-Esfarjani P, Fischbeck KH, Min KT. Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes Dev 17, 1463-1468, 2003.
Taylor JP, Tanaka F, Robitschek J, Markovic-Plese S, Taye AA, Sandoval CM, Fischbeck KH. Aggresomes protect cells by accelerating the degradation of polyglutamine-containing protein. Hum Molec Genet 12(7), 749-757, 2003.
La Spada AR, Taylor JP. Polyglutamines placed into context. Neuron 38, 681-684, 2003.
Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science 296(5575), 1991-1995, 2002.
