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Taylor: Sample publications 2010 or earlier

2010 Publications

Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandezz DG, Arepelli S, Chong S, Schymick JC, Rothstein J, Landi F, Wang M, Calvo A, Mora G, Sabatelli M, Monsurro MR, Battaistini S, Salvi F, Spataro R, Sola P, Borghero G, ITALSGEN, Galassi G, Scholz SW, Taylor JP, Restagno G, Chio A, Traynor BJ. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron 68(5):857-864, 2010.

Todd PK, Oh SY, Krans A, Pandey U, DiProspero N, Min KT, Taylor JP, and Paulson HL. Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome. PLoS Genetics 6(12):1240, 2010.

Nedelsky NB, Pennuto M, Smith RB, Palazzolo I, Nie Z, Moore J, Neale G and Taylor JP. Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy Neuron 67(6): 936-952, 2010.

Ritson GP, Custer SK, Freibaum BD, Guinto JB, Geffel D, Winton MJ, Neumann M, Trojanowski JQ, Lee VMY, Forman MS, Taylor JP. TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. J Neurosci 30(22):7729-39, 2010.

Lee JY, Nagano Y, Taylor JP, Lim KL, Yao TP. Parkin controls mitophagy by promoting mitochondrial ubiquitination and aggresome-like mitochondrial aggregate formation. J Cell Biol 189(4):671-9, 2010.

La Spada AR, Taylor JP. Repeat expansion disease: progress and puzzles in disease pathogenesis. Nature Reviews Genetics 11, 247-256, 2010.

Batlevi Y, Martin DN, Pandey UB, Simon CR, Powers CM, Taylor JP, Baehrecke EB. (2010) Dynein light chain 1 is required for autophagy, protein clearance and cell death in Drosophila. Proc Nat Acad Sci USA 107:742-747, 2010.

Freibaum BD, Chitta R, High AA, Taylor JP. Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. J Proteome Res 9:1104-1120, 2010.

Lee JY, Kawaguchi Y, Koga H, Tang W, Wong E, Pandey UB, Gao YS, Lu J, Taylor JP, Cuervo AM, Yao TP. HDAC6 controls autophagosome-lysosome fusion in basal homeostatic autophagy critical for protein aggregate clearance and neurodegeneration. EMBO J 29(5):969-980, 2010.

Tresse E, Salomons FA, Yao, TP, Dantuma NP, Taylor JP. VCP is essential for maturation of ubiquitin-containing autophagosomes. Autophagy 6, 217-227, 2010.

McCray BA, Skordalakes E, Taylor JP. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Human Molecular Genetics 19(6):1033-1047, 2010.

Custer SK, Neumann M, Lu H, Wright AC, Taylor JP. Transgenic mice expressing mutant forms of VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone. Human Molecular Genetics 19(9):1741-55, 2010.

Palazzolo I, Natalia Nedelsky NB, Askew C, Harmison G, Kasantsev AG, Taylor JP, Fischbeck KH, Pennuto M. B2 attenuates polyglutamine androgen receptor toxicity in spinal and bulbar muscular atrophy. J Neurosci Res 88(10):2207-16, 2010.

Lloyd T, Taylor JP. Flightless flies: Drosophila models of neuromuscular disease. Annals of the New York Acad Sci 1184:1-20, 2010.

Sample publications 2009 or earlier

Palazzolo I, Stack C, Kong L, Musaro A, Adachi H, Katsuno M, Sobue G, Taylor JP, Sumner C, Fischbeck KH, Pennuto M. Overexpression of IGF-1 attenuates disease in a mouse model of spinal and bulbar muscular atrophy. Neuron Aug 13;63(3):316-28, 2009.

Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neurons diseases. J Neurosci 29(25):8236-47, 2009.

Salajegheh M, Pinkus JL, Taylor JP, Amato AA, Nazareno R, Baloh RH, Greenberg SA. Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis. Muscle and NerveĀ­ 40(1):19-31, 2009.

Salomons FA, Menendez-Benito V, Bottcher C, McCray BA, Taylor JP, Dantuma NP. Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress. Mol Cell Biol 29(7):1774-1785, 2009.

Young J, Garden G, Martinez R, Tanaka F, Sandoval C, Smith A, Sopher B, Lin A, Fischbeck KH, Taylor JP, La Spada AR. Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. J Neurosci 29(7):1987-1997, 2009.

Taylor JP. Diagnosis and treatment of cerebellar ataxia in adults. In: UpToDate, Basow, DS, UpToDate, Waltham, MA, 2009.

Nedelsky NB, Todd PK, Taylor JP. Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochim Biophys Acta 1782(12), 691-699, 2009.

Pandey UB, Nie ZP, Batlevi Y, McCray BA, Ritson GP, Schwartz SL, DiProspero N, Knight M, Schuldiner O, Padmanabhan R, Hild M, Berry D, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the ubiquitin-proteasome system. Nature 447, 859-863, 2007.

Guinto, JB, Ritson GP, Taylor JP, Forman MS. Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy Acta Neuropath 114(1):55-61, 2007.

Neumann M, Mackenzie MD, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS. TDP-43 in ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol 66, 152-7, 2007.

Piccioni F, Romano B, Fischbeck KH, Taylor JP. A screen for drugs that protect against the toxicity of polyglutamine-expanded androgen receptor. Hum Molec Genet 13(4), 437-446, 2004.

Taylor JP, Taye AA, Campbell C, Kazemi-Esfarjani P, Fischbeck KH, Min KT.  Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes Dev 17, 1463-1468, 2003.

Taylor JP, Tanaka F, Robitschek J, Markovic-Plese S, Taye AA, Sandoval CM, Fischbeck KH. Aggresomes protect cells by accelerating the degradation of polyglutamine-containing protein. Hum Molec Genet 12(7), 749-757, 2003.

La Spada AR, Taylor JP. Polyglutamines placed into context. Neuron 38, 681-684, 2003.

Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science 296(5575), 1991-1995, 2002.