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Solid Tumor : Recurrent solid tumors
This is a phase I study of a virus called REOLYSIN. REOLSYIN has been developed from the naturally-occurring reovirus. Reovirus (Respiratory Enteric Orphan Virus) is a common virus that most people (70% to 100%) have been exposed to in their lifetime. REOLYSIN is considered experimental because it has not been approved by the Food and Drug Administration (FDA).
This is called a Phase I study because the goal is to find the highest dose of REOLYSIN that we can give safely. This Study focuses on REOLYSIN because it seems to work against cancer in test tubes and animals. The study team does not know if REOLYSIN will work in people. REOLYSIN is an unmodified virus that can make copies of itself inside the human body and possibly attack and destroy cancer cells. Because the patient’s body’s immune system might try to destroy the REOLYSIN, some participants enrolled later in the study will also take a drug called cyclophosphamide by mouth in an attempt to stop the body from destroying REOLYSIN. This will also help us find out if it is safe to give REOLYSIN and chemotherapy at the same time.
For the current eligibility status of this clinical study, referring physicians may contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).
Alberto Pappo, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
Referring or consulting physicians only: email@example.com
For all other inquiries about St. Jude Children's Research Hospital studies: firstname.lastname@example.org
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.