Michael R. Taylor, PhD

Michael R. Taylor, PhD

Assistant Member, St. Jude Faculty

Departments

Chemical Biology & Therapeutics

Contact Information

Michael Taylor, PhD
Chemical Biology & Therapeutics
MS 1000, Room E-9055
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: michael.taylor@stjude.org
Phone: (901) 595-6269
FAX: (901) 595-5715

Education

PhD – University of Washington, Seattle (2002)


Research Interests


Selected Publications

Eden CJ, Ju B, Murugesan M, Phoenix TN, Nimmervoll B, Tong Y, Ellison DW, Finkelstein D, Wright K, Boulos N, Dapper J, Thiruvenkatam R, Lessman CA, Taylor MR, Gilbertson RJ. Orthotopic models of pediatric brain tumors in zebrafish. Oncogene April 21, 2014.

Jia S, Muto A, Orisme W, Henson HE, Parupalli C, Ju B, Baier H, Taylor MR. Zebrafish Cacna1fa is required for cone photoreceptor function and synaptic ribbon formation. Hum Mol Genet January 12, 2014.

Ju B, Chen W, Spitsbergen JM, Lu J, Vogel P, Peters JL, Wang YD, Orr BA, Wu J, Henson HE, Jia S, Parupalli C, Taylor MR. Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway. Oncogenesis 3:e96, 2014.

Vrijens K, Lin W, Cui J, Farmer D, Low J, Pronier E, Zeng FY, Shelat AA, Guy K, Taylor MR, Chen T, Roussel MF. Identification of small molecule activators of BMP signaling. PLoS One 8(3):e59045, 2013.

Umans RA, Taylor MR. Zebrafish as a model to study drug transporters at the blood-brain barrier. Clin Pharmacol Ther 92(5):567-570, 2012.

Lessman CA, Taylor MR, Orisme W, Carver EA. Use of flatbed transparency scanners in zebrafish research: versatile and economical adjuncts to traditional imaging tools for the danio rerio laboratory. Methods Cell Biol 100:295-322, 2010.

Ju B, Spitsbergen J, Eden CJ, Taylor MR, Chen W. Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish. Mol Cancer 8(40):1-6, 2009.

Baraban SC, Dinday MT, Castro PA, Chege S, Guyenet S, Taylor MR. A large-scale mutagenesis screen to identify seizure-resistant zebrafish. Epilepsia 48:1151-7, 2007.

Kennedy BN, Alvarez Y, Brockerhoff SE, Stearns GW, Sapetto-Rebow B, Taylor MR, Hurley JB. Identification of a zebrafish cone photoreceptor-specific promoter and genetic rescue of achromatopsia in the nof mutant. Invest Ophthalmol Vis Sci 48:522-9, 2007.

Baraban SC, Taylor MR, Castro PA, Baier H. Pentylenetetrazole induced changes in zebrafish behavior, neural activity, and c-fos expression. Neuroscience 131:759-68, 2005.

Taylor MR, Kikkawa S, Ramamurthy V, Kawakami K, Brockerhoff SE.The Zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells. Genetics 170:263-73, 2005.

Taylor MR, Hurley JB, Van Epps HA, Brockerhoff SE. A zebrafish model for pyruvate dehydrogenase deficiency: rescue of neurological dysfunction and embryonic lethality using a ketogenic diet. Proc Natl Acad Sci USA 101:4584-9, 2004.

Brockerhoff SE, Rieke F, Matthews HR, Taylor MR, Cilluffo MC, Fain GL, Ankoudinova I, Xiao M, Niemi GA, Tucker CL, Hurley JB. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and a suppression of current in cones from the zebrafish mutant nof. J. Neurosci. 23:470-80, 2003.

Taylor MR, Van Epps HA, Kennedy MJ, Saari JC, Hurley JB, Brockerhoff SE. Biochemical analysis of phototransduction and visual cycle in zebrafish larvae. Methods in Enzymology 316:536-57, 2000.

Newburg DS, Peterson JA, Ruiz-Palacios GM, Matson DO, Morrow AL, Shults J, Guerrero MD, Chaturvedi P, Newburg SO, Scallan CD, Taylor MR, Ceriani RL, Pickering LK. Role of human-milk lactadherin in protection against symptomatic rotavirus infection. Lancet 351:1160-4, 1998.

Taylor MR, Couto JR, Scallan CD, Ceriani RL, Peterson JA. Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion. DNA Cell Biol 16:861-9. 1997.

Taylor MR, Peterson JA, Ceriani RL, Couto JR. Cloning and sequence analysis of human butyrophilin reveals a potential receptor function. Biochim Biophys Acta 1306:1-4, 1996.

Couto JR, Taylor MR, Godwin SG, Ceriani RL, Peterson JA. Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain. DNA Cell Biol 15:281-6, 1996.

Peterson JA, Couto JR, Taylor MR, Ceriani RL. Selection of tumor-specific epitopes on target antigens for radioimmunotherapy of breast cancer. Cancer Res 55:5847-51, 1995.

Last updated: May 2014