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Supportive Studies: Long Term Effects : osteosarcoma, Ewing sarcoma family of tumors, rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma
Anthracycline antibiotics are included in the chemotherapy regimens of approximately 82% of patients with bone cancer and 44% of those with soft tissue sarcoma diagnosed in childhood or adolescence. All children treated at St. Jude Children’s Research Hospital for osteosarcoma (the most common type of bone cancer, and the sixth most common type of cancer in children) or Ewing sarcoma family of tumors, most of those with intermediate or high-risk non-rhabdomyosarcoma soft tissue sarcoma(cancers that arise in the soft tissues of the body) and some with rhabdomyosarcoma (is a cancer made up of cells that normally develop into skeletal muscles) are treated with planned therapy that includes anthracycline. Impaired cardiac function occurs after treatment with anthracyclines. The frequency of impairment increases with increasing dose. The duration of the study will take place for 3 years.
The primary aim of this study is to evaluate imaging tests in previously untreated patients with osteosarcoma, ESFT, rhabdomyosarcoma and intermediate and high-risk non-rhabdomyosarcoma soft tissue sarcomas whose planned treatment includes a cumulative doxorubicin dose. This will determine if serial levels of one or more of these potential markers of cardiac muscle injury obtained prior to giving doxorubicin and at the completion of chemotherapy correlate with increasing cumulative anthracycline exposure.
Only current St. Jude patients are eligible for non-therapeutic studies.
Daniel Green, MD
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.