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A missing gene and the resulting slow connection between brain structures may leave individuals vulnerable to the “voices” that are a common symptom of schizophrenia.
St. Jude Children’s Research Hospital scientists report that a disruption in a brain circuit may contribute to the auditory hallucinations of schizophrenia. (Stanislav Zakharenko, MD, PhD)
Brain & Behavior Research Foundation
Society for Neuroscience
Congressman Steve Cohen Press Release
St. Jude investigators disprove a century-old theory, turning established scientific beliefs on their heads. This exciting discovery may someday have applications for such diseases as Alzheimer’s and Parkinson’s.
Stanislav Zakharenko, MD, PhD, Developmental Neurobiology, has been named a 2006 Searle Scholar, joining 15 of the country's most promising young scientists.
Disrupting the normal interaction between the genes PRODH and COMT contributes to major symptoms of schizophrenia by upsetting the balance of the brain chemicals glutamate and dopamine.