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Finding Cures. Saving Children.
Brain Tumor Program Featured Research
A list of recent featured research from the Brain Tumor team.
St. Jude Children’s Research Hospital and the University of Florida Proton Therapy Institute have formed a collaboration to provide proton therapy for St. Jude patients. The announcement follows the approval of the first clinical study to evaluate the use of proton therapy for rare brain cancers in children younger than 3 years old.
The most comprehensive study yet of long-term survivors of childhood central nervous system (CNS) tumors details risks some survivors face decades after their diagnosis, prompting a renewed call for improved follow-up care.
Scientists have found evidence suggesting that small-molecule drugs could offer the first effective chemotherapy for childhood low-grade astrocytomas, improving the prognosis for hundreds of children with the disease.
Researchers at St. Jude have demonstrated for the first time that tiny molecules called microRNAs participate in the initiation and progression of one form of human medulloblastoma, the most common malignant brain cancer in children.
Oncologists frequently use combinations of chemotherapy drugs as a knockout punch against tumors. The strategy has proven successful because it aims to jam the machinery of cancer cells in ways that are synergistic—fighting cancers more effectively than the individual drugs could alone.
Scientists at St. Jude have generated new models of medulloblastoma tumors by inactivating different DNA repair pathways, specifically in the brain.
St. Jude investigators have shown that children under 3 years old who have a brain tumor called diffuse pontine glioma (DPG) appear to have a better outcome than older children with the same cancer.
A discovery by St. Jude scientists suggests a safer way to treat medulloblastoma, a rare but often fatal childhood brain tumor. The group found that one of the brain’s signaling pathways inhibits the growth of the highly aggressive cancer cells.
