In order for our site to display correctly you will need a newer version of your web browser.
The following browsers support numerous web standards including CSS,XHTML, and the DOM (a universal means of controlling the behavior of web pages):
- Netscape v7 or higher (all platforms), Mozilla FireFox (Windows), Camino (Mac OS X), Galeon (Linux GNOME Desktop) or other browser stemming from the Mozilla.org project.
- Opera v7 or higher (Windows, Linux)
- Apple's Safari (Mac OS X)
- Konqueror (Linux KDE Desktop)
- Microsoft Internet Explorer v6 or higher (Windows) or v5 or higher (Macintosh)
Please note that this is not intended be an exhaustive list of browsers that support web standards, nor a test of browser compliance, nor a side-by-side comparison of various manufacturers’ browsers.
Finding Cures. Saving Children.
Paul A. Ney, MD
Associate Member, St. Jude Faculty
Departments
Biochemistry
Contact Information
Paul Ney, MD
Biochemistry
MS 340, Room D4063G
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: paul.ney@stjude.org
Phone: (901) 595-2049
FAX: (901) 525-8025
Education
MD - University of Wisconsin, Madison
Research Interests
-
Erythroid differentiation with an emphasis on mouse models and expression profiling
-
Erythropoietin receptor signaling
-
Friend virus-induced erythroleukemia
-
Globin gene regulation
Friend virus-induced erythroleukemia
Selected Publications
Zhang J, Ney PA. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death and Differentiation 2009 (in press).
Zhang J, Randall MS, Loyd M, Dorsey FC, Kundu M, Cleveland JL, Ney PA. Mitochondrial clearance is regulated by Atg7-dependent and independent mechanisms during reticulocyte maturation. Blood 2009 (in press).
Kundu M, Lindsten T, Yang C, Wu J, Zhao F, Zhang J, Selak MA, Ney PA, Thompson CB. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 112:1493-1502, 2008.
Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, Kundu M, Opferman JT, Cleveland JL, Miller JL, Ney PA. NIX is required for programmed mitochondrial clearance during reticulocyte maturation.Proc Nat Acad Sci USA 104:19500-19505, 2007. [see research highlight, Nat Rev Mol Cell Biol 10:89, 2009].
Xu W, Fukuyama T, Boyd K, Ney PA, Wang D, Rehg J, van Deursen J, Brindle PK. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B-cells. Blood 107:4407-4416, 2006.
Zhang J, Randall MS, Loyd MR, Li W, Schweers RL, Persons DA, Rehg JE, Noguchi CT, Ihle JN, Ney PA. Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia. Blood 107:73-78, 2006 [see commentary, pp. 5-6].
Dominici M, Tadjali M, Kepes S, Allay ER, Boyd K, Ney PA, Horwitz E, Persons DA. Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny. Genesis 42:17-22, 2005.
Zhou S, Zong Y, Ney PA, Nair G, Stewart CF, Sorrentino BP. Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels. Blood 105:2571-2576, 2005.
Loyd MR, Okamoto Y, Randall MS, Ney PA. Role of AP1/NFE2 binding sites in endogenous α-globin gene transcription. Blood 102:4223-4228, 2003.
Kasper LH, Boussouar F, Ney PA, Jackson CW, Rehg J, van Deursen JM, Brindle PK. A transcription factor binding surface of the coactivator p300 is essential for normal hematopoiesis. Nature 419:738-743, 2002.
Finkelstein LD, Ney PA, Liu QP, Paulson RF, and Correll PH. Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus. Oncogene 21:3562-3570, 2002.
Li YJ, Higgins RR, Pak BJ, Shivdasani RA, Ney PA, Archer M, Ben-David Y. p45 NFE2 is a negative regulator of erythroid proliferation which contributes to the progression of Friend virus-induced erythroleukemias. Mol Cell Biol 21:73-80, 2001.
Zang H, Sato K, Nakajima H, McKay C, Ney PA, Ihle JN. Non-essential role of the distal region of the Epo receptor or receptor tyrosines for in vivo erythropoiesis. EMBO J 20:3156-3166, 2001.
Ney PA, D’Andrea AD. Friend erythroleukemia revisited. Blood 96:3675-3680, 2000.
Persons DA, Paulson RF, Loyd MR, Herley MT, Bodner SM, Bernstein A, Correll PH, Ney PA. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nature Genet 23:159, 1999. [see also commentary, p. 128].
Mosser EA, Kasanov JD, Forsberg EC, Kay BK, Ney PA, Bresnick EH. Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains. Biochemistry 37:13686-13695, 1998.
Martin F, van Deursen JM, Shivdasani RA, Jackson CW, Troutman AG, Ney PA. Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and Nrf-2. Blood 91:3459-3466, 1998.
Bean TL, Ney PA. Multiple regions of p45 NF-E2 are required for beta-globin gene expression in erythroid cells. Nucleic Acids Res 25:2509-15, 1997.
Last update: May 2009
