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Geoffrey Neale

Geoffrey Neale, PhD

Administrative Director - Genomics
Hartwell Center for Bioinformatics and Biotechnology


Contact Information

Geoffrey Neale, PhD
Hartwell Center
MS312, Room D1007F
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: geoffrey.neale@stjude.org
Phone: (901) 595-3284


Education

PhD – University of Melbourne, Australia


Research Interests


Selected Publications

Ippagunta SK, Malireddi MRK, Shaw PJ, Neale GA, Walle LV, Green DR, Fukui Y, Lamkanfi M, Kanneganti TD. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat Immunol 12(10):1010-1016, 2011.

Yang K, Neale G, Green DR, He W, Chi H. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol 12(9):888-897, 2011.

Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 208(7):1367-1376, 2011.

Yang JJ, Cheng C, Devidas M, Cao X, Fan Y, Campana D, Yang W, Neale G, Cox NJ, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Willman CL, Bowman WP, Camitta BM, Carroll A, Reaman GH, Carroll WL, Loh M, Hunger SP, Pui CH, Evans WE, Relling MV. Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nat Genet February 6, 2011.

Kolb EA, Gorlick R, Houghton PJ, Morton CL, Neale G, Keir ST, Carol H, Lock R, Phelps D, Kang MH, Reynolds CP, Maris JM, Billups C, Smith MA. Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 55(4):668-677, 2010.

Pereira ER, Liao N, Neale GA, Hendershot LM. Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response. LID - e12521 [pii]. PLoS One 5(9):e12521, 2010.

Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein D, Pounds SB, Rand V, Leary SE, White E, Eden C, Hogg T, Northcott P, Mack S, Neale G, Wang YD, Coyle B, Atkinson J, Dewire M, Kranenburg TA, Gillespie Y, Allen JC, Merchant T, Boop FA, Sanford RA, Gajjar A, Ellison. Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature 466(7306):632-636, 2010.

Jiang J, Yu H, Shou Y, Neale G, Zhou S, Lu T, Sorrentino BP. Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cells. Blood 116(5):711-719, 2010.

Qualls JE, Neale G, Smith AM, Koo MS, Defreitas AA, Zhang H, Kaplan G, Watowich SS, Murray PJ. Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Sci Signal 3(135):ra62, 2010.

Nedelsky NB, Pennuto M, Smith RB, Palazzolo I, Moore J, Nie Z, Neale G, Taylor JP. Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. Neuron 67(6):936-952, 2010.

Trevino LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M, Willman C, Neale G, Downing J, Raimondi SC, Pui CH, Evans WE, Relling MV. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet 41(9):1001-1005, 2009.

Stepanov A, Nitiss KC, Neale GA, Nitiss JL.  Enhancing drug accumulation in Saccharomyces cerevisiae by repression of pleiotropic drug resistance genes with chimeric transcription repressors.  Mol Pharmacol 74:423-31, 2008.

Neale GA, Su X, Morton CL, Phelps D, Gorlick R, Lock RB, Reynolds CP, Maris JM, Friedman HS, Dome J, Khoury J, Triche TJ, Seeger RC, Gilbertson R, Khan J, Smith MA, Houghton PJ.  Molecular characterization of the pediatric preclinical testing panel.  Clin Cancer Res 14:4572-83, 2008.

French D, Yang W, Hamilton LH, Neale GA, Fan Y, Downing JR, Cox NJ, Pui CH, Evans WE, Relling MV.  Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs.  PLoS ONE 3:e2144, 2008.

Freeman SS, Allen SW, Ganti R, Wu J, Ma J, Su X, Neale GA, Dome JS, Daw NC, Khoury JD.  Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors.  Cancer 113:1453-61, 2008.

Hargrove PW, Kepes S, Hanawa H, Obenauer JC, Pei D, Cheng C, Gray JT, Neale GA, Persons DA.  Globin lentiviral vector insertions can perturb the expression of endogenous genes in beta-thalassemic hematopoietic cells.  Mol Ther 16:525-33, 2008.

Smith MA, Morton CL, Phelps D, Girtman K, Neale GA, Houghton PJ.  SK-NEP-1 and Rh1 are Ewing family tumor lines.  Pediatr Blood Cancer  50:703-6, 2008.

El Kasmi K, Smith AM, William L, Neale GA, Panopolous A, Watowich SS, Hacker H, Foxwell BMJ, Murray PJ.  Cutting edge: A transcriptional repressor and co-repressor induced by the STAT3-regulated anti-inflammatory signaling pathway.  J Immunol 179:7215-9, 2007.

Hartford C, Yang W, Cheng C, Fan Y, Liu W, Trevino L, Pounds S, Neale GA, Raimondi SC, Bogni A, Dolan ME, Pui CH, Relling MV.  Genome scan implicates adhesion biological pathways in secondary leukemia.  Leukemia, 21:2128-36, 2007.

Chen X, Hale GA, Neale GA, Knowles J, Barfield RC, Wang YD, Kaushal D, NaeveDC, Srivastava DK, Tong X, Turner V, Naeve CW, Handgretinger R.  A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation.  Exp Hematol 35:831-41, 2007.

Flotho C, Steinemann D, Mullighan CG, Neale GA, Mayer K, Kratz CP, Schlegelberger B, Downing JR, Niemeyer CM.  Genome-wide single nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11. Oncogene 26:5816-21, 2007.

West AN, Neale GA, Pounds S, Figueredo BC, Rodriguez Galindo C, Pianovski MA, Oliveira Filho AG, Malkin D, Lalli E, Ribeiro R, Zambetti GP.  Gene expression profiling of childhood adrenocortical tumors.  Cancer Res 67:600-8, 2007.

Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons DM.  An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.  Cancer Res 67:573-9, 2007.

Denson J, Xi Z, Wu Y, Yang W, Neale G, Zhang J.  Screening for inter-individual splicing differences in human GSTM4 and the discovery of a single nucleotide substitution related to the tandem skipping of two exons.  Gene 379:148-55, 2006.

Carella C, Potter M, Bonten J, Rehg JE, Neale GA, Grosveld GC.  The ETS factor TEL2 is a hematopoietic oncoprotein.  Blood 107:1124-1132, 2006.

Harris L, Davenport J, Neale G, Goorha R.  The mitotic checkpoint gene BubR1 has two distinct functions in mitosis.  Exp Cell Res 308:85-100, 2005.

Marshall DR, Olivas E, Andreansky S, La Gruta NL, Neale GA, Gutierrez A, Wichlan DG, Wingo S, Cheng C, Doherty PC, Turner SJ.  Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression.  PNAS 102:6074-6079, 2005.

Nilsson JA, Keller UB, Baudino TA, Yang C, Norton S, Old JA, Nilsson LM, Neale GA, Kramer DL, Porter CW, Cleveland JL.  Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.  Cancer Cell 7:433-444, 2005.

Chen X, Barfield R, Benaim E, Leung W, Knowles J, Lawrence D, Otto M, Shurtleff SA, Neale GA, Behm FG, Turner V, Handgretinger R.  Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients.  Blood 105:886-893, 2005.

NealeGA, Coustan-Smith E, Stow P, Pan Q, Chen X, Pui CH, Campana D.  Comparative analysis of flow cytometry and polymerase chain reaction for the detection of minimal residual disease in childhood acute lymphoblastic leukemia.  Leukemia 18:934-938, 2004.

Chen X, Pan Q, Stow P, Behm F, Goorha R, Pui C-H, Neale GA.  Quantification of minimal residual disease in T-lineage acute lymphoblastic leukemia with the TAL-1 deletion using a standardized real-time PCR assay.  Leukemia 15:166-70, 2001.