Laura Janke, DVM, PhD, DACVP

Assistant Member, St. Jude Faculty

Departments

Pathology

Contact Information

Laura Janke, DVM, PhD, DACVP
Pathology
MS 250, Room C5036
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: laura.janke@stjude.org
Phone: (901) 595-3165
FAX: (901) 595-3100

Education

BA – Concordia College, Moorhead, Minnesota (1996)
PhD – University of Minnesota, St.Paul, MN (2004)
DVM – University of Minnesota, College of Veterinary Medicine, St. Paul, MN (2006)
ACVP, Diplomate - University of Minnesota, Veterinary Diagnostic Laboratory, St. Paul, MN (2009)

Research Interests

• Phenotyping of genetically engineered mice
• Assessment of treatment efficacy and toxicity in mouse models of pediatric cancers
• Use of immunohistochemistry to aid in the investigation of tissue- and cell-specific molecular changes
• Use of histomorphometry and whole slide imaging to assist in the generation of objective data regarding histopathological lesions or antigen expression

Selected Publications

Kawedia JD, Janke L, Funk AJ, Ramsey LB, Liu C, Jenkins D, Boyd KL, Relling MV. Substrain-specific differences in survival and osteonecrosis incidence in a mouse model of osteonecrosis. Comparative Medicine 2013 (in press).

Dillon CP, Oberst A, Weinlich R, Janke LJ, Kang T-B, Ben-Moshe T, Mak TW, Wallach D, Green DR. Survival Function of the FADD-CASPASE-8-cFLIPL Complex. Cell Reports May;1:401-407, 2012.

Picchione F, Pritchard C, Lagutina I, Janke L, Grosveld GC. IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS). Carcinogenesis Apr;32(4):452-61, 2011.

Janke L, Carlson CS, St. Hill CA. The Novel Carbohydrate Tumor Antigen C2-O-sLe^x is Upregulated in Canine Gastric Carcinomas. Vet Pathol May;47(3):455-461, 2010.

Khasabova IA, Stucky CL, Harding-Rose C, Eikmeier L, Beitz AJ, Coicou LG, Hanson AE, Simone DA, Seybold VS. Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer pain. J Neurosci Sep 19;27(38):10289-98, 2007.

Vit JP, Ohara PT, Tien DA, Fike JR, Eikmeier L, Beitz A, Wilcox GL, Jasmin L. The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception. Pain Jan;120(1-2):188-201, 2006.

Wacnik PW, Eikmeier LJ, Simone DA, Wilcox GL, Beitz AJ. Nociceptive Characteristics of Tumor Necrosis Factor-α in Naïve and Tumor-bearing Mice. Neuroscience 132(2):479-91, 2005.

Wacnik PW, Eikmeier LJ, Ruggles TR, Ramnaraine ML, Walcheck BK, Beitz AJ, GL Wilcox. Functional interactions between tumor and peripheral nerve: morphology, algogen identification and behavioral characterization of a new murine model of cancer pain. Journal of Neuroscience 21, 9355-9366, 2001.

Last updated February 2013