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The new Translational Trials Unit (TTU) provides an outpatient site for Phase I and II clinical trials of novel therapeutic or prophylactic agents. The unit works with basic science investigators to guide translational trial design and facilitate regulatory approval for on-site trials or cooperative efforts. It also assists in the conduct and analysis of on-site Phase I and II studies. The unit has 12 clinic rooms and an adjacent laboratory that processes, stores, distributes, and ships clinical research specimens. The unit allows the conduct of 10 to 20 additional Phase I protocols per year and the simultaneous conduct of 2 Phase II trials. Because the TTU is a core facility, it manages multiple, concurrent scientifically diverse trials. The unit is currently investigating a parainfluenza virus vaccine, 3 AIDS vaccines, and a cholera vaccine. It houses the endocrine clinic, HIV Program and Sickle Cell Program.