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Finding Cures. Saving Children.
Leta K. Nutt, PhD
Assistant Member, St. Jude Faculty
Departments
Biochemistry
Contact Information
Leta Nutt, PhD
Biochemistry
MS340, Room D4063D
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: leta.nutt@stjude.org
Phone: (901) 595-6530
FAX: (901) 525-8025
Education
PhD – University of Texas M.D. Anderson Health Science Center, Graduate School of Biomedical Sciences, Houston (2002)
Research Interests
- Metabolic regulation of apoptosis
- Calcium homeostasis during apoptosis
- Metabolic regulation of ER stress
Selected Publications
Nutt LK, Buchakjian MR, Gan E, Darbandi R, Yoon SY, Qiju Wu J, Miyamoto YJ, Gibbon JA, Andersen JL, Freel CD, He C, Kurokawa M, Margolis S, Fissore RA, Kornbluth S. Metabolic control of oocyte apoptosis mediated by 14-3-3-regulated dephosphorylation of caspase-2. Dev Cell 16(6):856-866, 2009. (Featured Article)
Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, Hanh WC, Virshup DM, Kornbluth S. Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell Nov 17;127(4):759-73, 2006.
Walterscheid JP, Nghiem DX, Kazimi N, Nutt LK, McConkey DJ, Norval M, Ullrich SE. Cisurocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor. Proc Natl Acad Sci USA Nov 14;103(46):17420-5, 2006.
Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC, Kornbluth S. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase 2. Cell Oct 7;123(1):89-103, 2005. (Cover Story)
Bustamante J, Nutt L, Orrenius S, Gogvadze V. Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition. Toxicol Appl Pharmacol Sep 1;207(2 Suppl):110-6, 2005.
Nutt LK, Gogvadze V, Uthaisang W, Mirnikjoo B, McConkey DJ, Orrenius S. Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis. Cancer Biol Ther Apr;4(4):459-67, 2005.
Casaletto JB, Nutt LK, Wu Q, Moore JD, Etkin LD, Jackson PK, Hunt T, Kornbluth S. Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. J Cell Biol Apr 11;169(1):61-71, 2005.
Daré E, Tofighi R, Nutt L, Vettori MV, Emgård M, Mutti A, Ceccatelli S. Styrene 7,8-oxide induces mitochondrial damage and oxidative stress in neurons. Toxicology Sep 1;201(1-3):125-32, 2004.
McConkey DJ, Nutt L. Measurement of changes in intracellular calcium during apoptosis. Methods Mol Biol 282:117-30, 2004.
Uthaisang W, Nutt LK, Orrenius S, Fadeel B. Phosphatidylserine exposure in Fas type I cells is mitochondria-dependent. FEBS Lett Jun 19;545(2-3):110-4, 2003.
Nutt LK, Chandra J, Patear A, Roth J, Swisher S, O'Neil RG, McConkey DJ. Bax-mediated Ca2+ mobilization promotes cytochrome c release in apoptosis. J Biol Chem Jun 7; 277(23): 20301-8, 2002.
Nutt LK, Patear A, Pahler JC, Roth J, McConkey DJ, Swisher S. Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores. J Biol Chem Mar 15; 277(11): 9219-25, 2002.
McConkey DJ, Nutt LK. Calcium flux measurements in apoptosis. Methods Cell Biol 66:229-46, 2001.
Nutt LK, O’Neil RG. Effect of elevated glucose on endothelin-induced, store-operated and nonstore-operated calcium influx in renal mesangial cells. J Am Soc Nephrol 11:1225-1235, 1999.
McConkey DJ, Lin Y, Nutt LK, Ozel HZ, Newman RA. Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. Cancer Research 60:14:3807-38012, 1999.
Last update July 2009
