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Finding Cures. Saving Children.
Richard J. Webby, PhD
Associate Member, St. Jude Faculty
Director, World Health Organization Collaborating Center for Studies on the Ecology of Influenza in Animals and Birds
Departments
Infectious Diseases
Divisions
Virology
Contact Information
Richard Webby, PhD
Infectious Diseases
MS 330, Room E-9056
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: richard.webby@stjude.org
Phone: (901) 595-3014
FAX: (901) 595-8559
Education
PhD - University of Otago, New Zealand
Research Interests
- Influenza virus ecology
- Influenza vaccination
- Influenza virus pathogenicity
- Determinants of host susceptibility to influenza
Selected Publications
Bahgat MM, Kutkat MA, Nasraa MH, Mostafa A, Webby R, Bahgat IM, Ali MA. Characterization of an avian influenza virus H5N1 Egyptian isolate. J Virol Methods E published May 3, 2009.
Lee JH, Pascua PN, Song MS, Baek YH, Kim CJ, Choi HW, Sung MH, Webby RJ, Webster RG, Poo H, Choi YK. Isolation and genetic characterization of H5N2 influenza viruses from pigs in Korea. J Virol May;83(9):4205-15, 2009.
Thomas PG, Dash P, Aldridge JR Jr, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity Apr;30(4):566-75, 2009.
Yen HL, Aldridge JR, Boon AC, Ilyushina NA, Salomon R, Hulse-Post DJ, Marjuki H, Franks J, Boltz DA, Bush D, Lipatov AS, Webby RJ, Rehg JE, Webster RG. Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread. Proc Natl Acad Sci USA 106:286-91, 2009.
Hartshorn KL, Webby R, White MR, Tecle T, Pan C, Boucher S, Moreland RJ, Crouch EC, Scheule RK. Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D. Respir Res 9:65, 2008.
Kedzierska K, Guillonneau C, Gras S, Hatton LA, Webby R, Purcell AW, Rossjohn J, Doherty PC, Turner SJ.Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy. Proc Natl Acad Sci USA 105:19408-13, 2008.
Wan H, Sorrell EM, Song H, Hossain MJ, Ramirez-Nieto G, Monne I, Stevens J, Cattoli G, Capua I, Chen LM, Donis RO, Busch J, Paulson JC, Brockwell C, Webby R, Blanco J, Al-Natour MQ, Perez DR. Replication and transmission of H9N2 influenza viruses in ferrets: evaluation of pandemic potential. PLoS ONE 3(8): 2008.
Sandbulte MR, Boon ACM, Webby RJ, Riberdy JM. Analysis of cytokine secretion from human plasmacytoid dendritic cells infected with H5N1 or low-pathogenicity influenza viruses. Virology 381(1):22-8, 2008.
Webby RJ, Sandbulte MR. Influenza vaccines. Front Biosci 13:4912-24, 2008.
Lalor PA, Webby RJ, Morrow J, Rusalov R, Kaslow DC, Rolland A, Smith LR. Plasmid DNA-based Vaccines Protect Mice and Ferrets against Lethal Challenge with A/Vietnam/1203/04 (H5N1) Influenza Virus. J Infect Dis 197:1643-1652, 2008.
Boon AC, Sandbulte MR, Seiler P, Webby RJ, Songserm T, Guan Y, Webster RG. Role of terrestrial wild birds in ecology of influenza A virus (H5N1). Emerg Infect Dis 13:1720-4, 2008.
Vincent AL, Ma W, Lager KM, Janke BH, Webby RJ, García-Sastre A, Richt JA. Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine. Vaccine 25:7999-8009, 2007.
Krauss S, Obert CA, Franks J, Walker D, Jones K, Seiler P, Niles L, Pryor SP, Obenauer JC, Naeve CW, Widjaja L, Webby RJ, Webster RG. Influenza in migratory birds and evidence of limited intercontinental virus exchange. PLoS Pathog 3(11):e167, 2007.
Webby RJ, Webster RG, Richt JA. Influenza viruses in animal wildlife populations. Curr Top Microbiol Immunol 315:67-83, 2007.
Ma W, Vincent AL, Gramer MR, Brockwell CB, Lager KM, Janke BH, Gauger PC, Patnayak DP, Webby RJ, Richt JA. Identification of H2N3 influenza A viruses from swine in the United States. Proc Natl Acad Sci USA 104:20949-54, 2007.
Hulse-Post DJ, Franks J, Boyd K, Salomon R, Hoffmann E, Yen HL, Webby RJ, Walker D, Nguyen TD, Webster RG. Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J Virol 81(16):8515-24, 2007.
Thomas PG, Brown SA, Keating, R, Yue W, Morris MY, So J, WebbyRJ,Doherty PC. Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses. J Immunol 178:3091-8, 2007.
Sandbulte MS, Jimenez GS, Boon ACM, Smith LR, Treanor JT, Webby RJ. Cross-Reactive Neuraminidase Antibodies Afford Partial Protection against H5N1 Infection in Mice and are Present in Unexposed Humans. PLoS Medicine 13:4(2):e59, 2007.
Lee YJ, Shin JY, Song MS, Lee YM, Choi JG, Lee EK, Jeong OM, Sung HW, Kim JH, Kwon YK, Kwon JH, Kim CJ, Webby RJ, Webster RG, Choi YK. Continuing evolution of H9 influenza viruses in Korean poultry. Virology 359:313-23, 2006.
Hanson BJ, Boon AC, Lim AP, Webb A, Ooi EE, Webby RJ. Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice. Respir Res 17:126, 2006.
Richt JA, Lekcharoensuk P, Lager KM, Vincent AL, Loiacono CM, Janke BH, Wu WH, Yoon KJ, Webby RJ, Solorzano A, Garcia-Sastre A. Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine. J Virol 80:11009-11018, 2006.
Shin JY, Song MS, Lee EH, Lee YM, Kim SY, Kim HK, Choi JK, Kim CJ, Webby RJ, Choi YK. Isolation and characterization of novel H3N1 swine influenza viruses from pigs with respiratory diseases in Korea. J Clin Microbiol 44:3923-3927, 2006.
Jenkins MR, Webby R, Doherty PC, Turner SJ. Addition of a prominent epitope affects Influenza A virus-specific CD8+ T cell immunodominance hierarchies when antigen is limiting. J Immunol 177: 2917-2925, 2006.
Gill JS, Webby R, Gilchrist MJR, Gray GC. Avian influenza infection in waterfowl hunters and wildlife professionals. Emerg Infect Dis 12:1284-1286, 2006.
Macken CA, Webby RJ, Bruno WJ. Genotype turnover by reassortment of replication complex genes from avian influenza A virus. J Gen Virol 87:2803-2815, 2006.
Govorkova EA, Webby RJ, Humberd JH, Seiler JP, Webster RG. Immunization with reverse genetics H5N1 influenza vaccine protects ferrets against homologous and heterologous challenge. J Infect Dis 194:159-167, 2006.
Webster RG, Webby RJ, Hoffmann E, Rodenberg J, Kumar M, Seiler P, Krauss S, Songserm T. The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens. Virology 351:303-311, 2006.
Hyland L, Webby R, Sandbulte MR, Clarke B, Sam H. Influenza virus NS1 protein protects against lymphohematopoietic pathogenesis in an in vivo mouse model. Virology 349:156-163, 2006.
Widjaja L, Webster RG, Ilyushina N, Webby RJ. Molecular changes associated with adaptation of human influenza A virus in embryonated chicken eggs. Virology 350:137-145, 2006.
Lodes MJ, Suciu D, Elliott M, Stover AG, Ross M, Caraballo M, Dix K, Crye J, Webby RJ, Lyon WJ, Danley, DL, McShea A. Use of Semiconductor-Based Oligonucleotide Microarrays for Influenza A Virus Subtype Identification and Sequencing. J Clin Microbiol 44: 1209-1218, 2006.
Doherty PC, Turner SJ, Webby RJ, Thomas PG. Influenza and the challenge for immunology. Nat Immunol 7:449-455, 2006.
Thomas PG, Brown SA, Yue W, So J, Webby RJ, Doherty PC. An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses. Proc Natl Acad Sci USA 103:2764-2769, 2006.
Wei L, Sandbulte MR, Thomas PG, Webby RJ, Homayouni R, Pfeffer LM. NFkB negatively regulates interferon-induced gene expression and anti-influenza activity. J Biol Chem 28:11678-11684, 2006.
Salomon R, Franks J, Govorkova EA, Ilyushina NA, Yen HL, Hulse-Post DJ, Humberd J, Trichet M, Rehg JE, Webby RJ, Webster RG, Hoffmann E. The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J Exp Med 203:689-697, 2006.
La Gruta L, Kedzierska K, Pang K, Webby R, Davenport M, Chen W, Turner SJ, Doherty PC. A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies. Proc Natl Acad Sci USA 103:994-999, 2006.
Hawkins MG, Crossley BM, Osofsky A, Webby RJ, Lee CW, Suarez DL, Hietala SK. Avian influenza A virus subtype H5N2 in a red-lored Amazon parrot. J Am Vet Med Assoc 228:236-241, 2006.
Avadhanula V, Rodriguez CA, DeVincenzo JP, Wang Y, Webby RJ, Ulett GC, Adderson EE. Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species and cell type-dependent manner. J Virol 80:1629-1636, 2006.
Last update: June 2009
