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St. Jude scientists identify key molecular events in pediatric adrenocortical tumors. The findings could help clinicians identify most malignant subtypes and lead to better treatment.
Nine-year-old Matthew Fox doesn’t talk much about the fact that he was found to have cancer when he was 4 years old. His mother, Freda, says most people have a hard time believing that the third-grader battled Burkitt lymphoma, a cancer in which immune cells called B lymphocytes turn malignant and proliferate uncontrollably.
St. Jude investigators have found that a protein called Puma, which normally protects the body by triggering cancer cells to commit suicide through a process called apoptosis, is suppressed in Burkitt lymphoma.
The discovery of an unexpected mutation in a patient supports researchers' belief that different mutations in the same cancer preventing gene--p53--can have vastly different medical consequences.
St. Jude researchers are part of a team that has synthesized one of the body's most important defenses against the development of tumors.
Proof that PUMA stalks cancer cells solves a long-standing mystery of the anti-cancer role of p53
Why are children in southern Brazil more susceptible to a rare type of cancer than children in other parts of the world? St. Jude researchers and clinicians spend more than a decade unraveling the mystery.