Disease Information

Stem Cell / Bone Marrow Transplant: Autologous Stem Cell Transplantation (SCT)

Alternate Names: SCT

Definition

Autologous stem cell transplant (SCT) / bone marrow transplant is used to treat a variety of malignant diseases, such as neuroblastoma, Ewing sarcoma, lymphomas and selected brain tumors.

Stem Cell Source
Autologous blood stem cells may be collected from the bone marrow by bone marrow harvest or from the peripheral blood through IV’s after treatment with GCSF.

Survival Rates

The survival rates differ by diagnosis and disease status.

Treatment Strategies

This form of treatment generally requires pre-transplant conditioning therapy with high-dose chemotherapy and/or radiation therapy and immunosuppressive antibodies. This is followed by infusion of the stem cells via a central venous catheter. Patients then require careful monitoring for infection, blood product support and antibiotic therapy.

Current Research

Autologous stem cell transplant / bone marrow transplant is used for the treatment of advanced or refractory solid tumors. The major problem associated with this treatment is relapse after transplantation. At St. Jude Children’s Research Hospital we are investigating different chemotherapies for pre-transplant conditioning to prevent relapse. We are also investigating post-stem cell transplant / bone marrow transplant immunotherapy to prevent relapse.

 

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