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Finding Cures. Saving Children.
Disease Information
Stem Cell / Bone Marrow Transplant: Autologous Stem Cell Transplantation (SCT)
Alternate Names: SCT
Definition
Autologous stem cell transplant (SCT) / bone marrow transplant is used to treat a variety of malignant diseases, such as neuroblastoma, Ewing sarcoma, lymphomas and selected brain tumors.
Stem Cell Source
Autologous blood stem cells may be collected from the bone marrow by bone marrow harvest or from the peripheral blood through IV’s after treatment with GCSF.
Survival Rates
The survival rates differ by diagnosis and disease status.
Treatment Strategies
This form of treatment generally requires pre-transplant conditioning therapy with high-dose chemotherapy and/or radiation therapy and immunosuppressive antibodies. This is followed by infusion of the stem cells via a central venous catheter. Patients then require careful monitoring for infection, blood product support and antibiotic therapy.
Current Research
Autologous stem cell transplant / bone marrow transplant is used for the treatment of advanced or refractory solid tumors. The major problem associated with this treatment is relapse after transplantation. At St. Jude Children’s Research Hospital we are investigation different chemotherapies for pre-transplant conditioning to prevent relapse. We are also investigating post-stem cell transplant / bone marrow transplant immunotherapy to prevent relapse.
The St. Jude Web site is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through this site should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider.
