HAPNK1: KIR Mismatched Haploidentical Donor Hematopoietic Progenitor Cell and Natural Killer Cell Transplantation with a TLI Based Conditioning Regimen in Patients with Hematologic Malignancies


Stem Cell / Bone Marrow Transplant : Hematological malignancies

Description (Donor)

Apheresis is a routine procedure (non-research) for obtaining blood progenitor cells from adult donors to be used for transplantation. Blood progenitor cells are immature (young) cells that usually live in the bone marrow. These cells can become any type of blood cell - a white cell to fight infection, a red cell to carry oxygen, or a platelet to clot the blood.

Donors will undergo collections at two separate periods for the purposes of this research study. The first collections will be for the progenitor cells used in the primary transplant infusion. The second collection procedure, approximately one week after the first collection, will be filtered specifically for NK cells.

Description (Recipient)

You are being invited to join this study because you have a type of cancer affecting the blood or lymphatic system that is difficult to treat. At this time, the cancer has either 1) disappeared (remission), 2) come back (relapsed) or, 3) not responded well (refractory) after very intensive therapy.

The side effects of any type of hematopoietic cell transplant can be severe and life threatening, and may even cause death. There is no promise that you will survive the transplant or be cured of your disease. It is important that you understand the possible risks and benefits before you agree to this treatment.

Objectives (Recipient)

Eligibility Criteria, among others, include (Recipient)

For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).


Brandon, Triplett, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
FAX: 901-595-4011

Referring or consulting physicians only:

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.